Uptake, Biological Fate, and Toxicity of Metal Oxide Nanoparticles (pages 24–35)
Jordi Llop, Irina Estrela-Lopis, Ronald F. Ziolo, Africa González, Jana Fleddermann, Marco Dorn, Vanessa Gomez Vallejo, Rosana Simon-Vazquez, Edwin Donath, Zwengei Mao, Changyou Gao and Sergio E. Moya
Article first published online: 21 DEC 2013 | DOI: 10.1002/ppsc.201300323
The study of the biological fate of metal oxide nanoparticles is fundamental to understand their possible toxicological action. The biodistribution, organ accumulation, and fate of radiolabelled metal oxide nanoparticles have been determined in animal models by means of positron emission tomography for different exposure ways. At the cellular level, ion beam microscopy was applied to quantify the intracellular dose of label-free nanoparticles and to asset their localization.