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Body-mass index as a predictor of incident asthma in a prospective cohort of children†
Article first published online: 10 NOV 2003
Copyright © 2003 Wiley-Liss, Inc.
Volume 36, Issue 6, pages 514–521, December 2003
How to Cite
Gold, D. R., Damokosh, A. I., Dockery, D. W. and Berkey, C. S. (2003), Body-mass index as a predictor of incident asthma in a prospective cohort of children. Pediatr. Pulmonol., 36: 514–521. doi: 10.1002/ppul.10376
- Issue published online: 10 NOV 2003
- Article first published online: 10 NOV 2003
- Manuscript Accepted: 17 JUL 2003
- Manuscript Revised: 19 JUN 2003
- Manuscript Received: 13 FEB 2003
- U.S. Environmental Protection Agency. Grant Number: CR821762
- National Institute of Allergy and Infectious Diseases. Grant Number: RO1 AI/EHS35786
- National Institute of Environmental Health Sciences
- Boston Medical Center. Grant Number: Boston Obesity Nutrition Research Grant DK 42600
- maternal smoking
An epidemic rise in asthma has occurred concurrently with a rise in overweight among United States children, but it is unclear whether body weight affects the risk of incident childhood asthma. We studied the prospective relation of body-mass index (BMI) to incident asthma in a longitudinal study of 9,828 children aged 6–14 years, examined annually over a median follow-up time of 5 years in six US cities. An increased risk of a new asthma diagnosis in girls was associated with higher BMI at entry into the study (P = 0.009) and greater increase in BMI during follow-up (P = 0.0003). Compared with girls in the leanest quintile of BMI at entry (age taken into account), girls in the top quintile of adiposity had 2.2 times greater risk of incident asthma with any wheeze in subsequent years. Girls with the largest annual rate of increase in BMI (top compared to bottom quintile, age taken into account) had 1.5 times the risk of asthma with any wheeze, and 2.2 times the risk of asthma with persistent wheeze. Boys with the largest and smallest annual changes in BMI also had an increased risk of asthma. For girls, overweight contributes to development of asthma. For boys and girls, extremes of annual BMI growth rates increase the risk of asthma. Pediatr Pulmonol. 2003; 36:514–521. © 2003 Wiley-Liss, Inc.