Diagnostic and Therapeutic Methods

Use of computerized tomography and chest X-rays in evaluating efficacy of aerosolized recombinant human DNase in cystic fibrosis patients younger than age 5 years: A preliminary study†

  1. Samya Z. Nasr MD*,
  2. Lawrence R. Kuhns MD,
  3. Randall W. Brown MD,
  4. Martin E. Hurwitz MD,
  5. Georgiana M. Sanders MD,
  6. Peter J. Strouse MD

Article first published online: 30 APR 2001

DOI: 10.1002/ppul.1061

Issue

Pediatric Pulmonology

Pediatric Pulmonology

Volume 31, Issue 5, pages 377–382, May 2001

Additional Information

How to Cite

Nasr, S. Z., Kuhns, L. R., Brown, R. W., Hurwitz, M. E., Sanders, G. M. and Strouse, P. J. (2001), Use of computerized tomography and chest X-rays in evaluating efficacy of aerosolized recombinant human DNase in cystic fibrosis patients younger than age 5 years: A preliminary study. Pediatr. Pulmonol., 31: 377–382. doi: 10.1002/ppul.1061

Author Information

  1. Sections of Pediatric Pulmonary and Radiology, Departments of Pediatrics, University of Michigan Medical Center, Ann Arbor, Michigan

*Department of Pediatrics, University of Michigan Medical Center, 1500 E. Medical Center Drive, Ann Arbor, MI 48109–0212.

  • †

    Presented in part at the International Conference for the American Thoracic Society, April 23–28, 1999, and at the North American Annual Cystic Fibrosis Conference, October 7–10, 1999.

Publication History

  1. Issue published online: 30 APR 2001
  2. Article first published online: 30 APR 2001
  3. Manuscript Accepted: 12 JAN 2001
  4. Manuscript Received: 29 MAR 2000

Funded by

  • NIH. Grant Number: MO1-RR000042
  • Genentech, Inc.
  • Dale Maxwell Memorial Funds

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

Get PDF (150K)

Cited in:

CrossRef

This article has been cited by:

  1. 1
    Peter J. Mogayzel, Edward T. Naureckas, Karen A. Robinson, Gary Mueller, Denis Hadjiliadis, Jeffrey B. Hoag, Lisa Lubsch, Leslie Hazle, Kathy Sabadosa, Bruce Marshall, Cystic Fibrosis Pulmonary Guidelines, American Journal of Respiratory and Critical Care Medicine, 2013, 187, 7, 680

    CrossRef

  2. 2
    Hartmut Grasemann, Felix Ratjen, Early lung disease in cystic fibrosis, The Lancet Respiratory Medicine, 2013, 1, 2, 148

    CrossRef

  3. 3
    Hüseyin Altunhan, Ali Annagür, Sevgi Pekcan, Rahmi Örs, Hasan Koç, Comparing the efficacy of nebulizer recombinant human DNase and hypertonic saline as monotherapy and combined treatment in the treatment of persistent atelectasis in mechanically ventilated newborns, Pediatrics International, 2012, 54, 1
    Direct Link:
  4. 4
    Robert S. Bercovitch, Sheila C. Tsai, Respiratory medications and sleep, Current Respiratory Care Reports, 2012, 1, 2, 123

    CrossRef

  5. 5
    Amy G. Filbrun, Carey N. Lumeng, Samya Z. Nasr, Infant pulmonary function testing guides therapy in cystic fibrosis lung disease, Respiratory Medicine CME, 2011, 4, 1, 17

    CrossRef

  6. 6
    P. A. Jong, J. A. Achterberg, O. A. M. Kessels, B. Ginneken, L. Hogeweg, F. J. Beek, S. W. J. Terheggen-Lagro, Modified Chrispin-Norman chest radiography score for cystic fibrosis: observer agreement and correlation with lung function, European Radiology, 2011, 21, 4, 722

    CrossRef

  7. 7
    Monika Eichinger, Claus-Peter Heussel, Hans-Ulrich Kauczor, Harm Tiddens, Michael Puderbach, Computed tomography and magnetic resonance imaging in cystic fibrosis lung disease, Journal of Magnetic Resonance Imaging, 2010, 32, 6
    Direct Link:
  8. 8
    Pavithra Raman, Raghav Raman, Beverley Newman, Raman Venkatraman, Bhargav Raman, Terry E. Robinson, Development and Validation of Automated 2D–3D Bronchial Airway Matching to Track Changes in Regional Bronchial Morphology Using Serial Low-Dose Chest CT Scans in Children with Chronic Lung Disease, Journal of Digital Imaging, 2010, 23, 6, 744

    CrossRef

  9. 9
    H. William Kelly, Mucolytic Therapy: What, When, Where, Why, and What Is the Evidence?, Pediatric Allergy, Immunology, and Pulmonology, 2010, 23, 2, 151

    CrossRef

  10. 10
    Helmut Ellemunter, Susanne I. Fuchs, Karin M. Unsinn, Martin C. Freund, Maria Waltner-Romen, Gratiana Steinkamp, Monika Gappa, Sensitivity of lung clearance index and chest computed tomography in early cf lung disease, Respiratory Medicine, 2010, 104, 12, 1834

    CrossRef

  11. 11
    Samya Z. Nasr, Ermelinda Sakmar, Emmanuel Christodoulou, Boris P. Eckhardt, Daniel S. Streetman, Peter J. Strouse, The use of high resolution computerized tomography (HRCT) of the chest in evaluating the effect of tobramycin solution for inhalation in cystic fibrosis lung disease, Pediatric Pulmonology, 2010, 45, 5
    Direct Link:
  12. 12
    D. Hughes, H. Tiddens, J.M. Wild, Lung Imaging in Cystic Fibrosis, Imaging Decisions MRI, 2009, 13, 1
    Direct Link:
  13. 13
    Clement L Ren, Assessment and monitoring of cystic fibrosis lung disease in infants and young children, Expert Review of Respiratory Medicine, 2008, 2, 3, 381

    CrossRef

  14. 14
    Raj Padman, Lloyd N. Werk, Gabriela Ramirez-Garnica, Gang Ye, Ian Nathanson, Association between practice patterns and body mass index percentile in infants and young children with cystic fibrosis, Journal of Cystic Fibrosis, 2008, 7, 5, 385

    CrossRef

  15. 15
    Stephen M. Stick, Clinical trials in infants with cystic fibrosis detected following newborn screening, Paediatric Respiratory Reviews, 2008, 9, 3, 176

    CrossRef

  16. 16
    Barry Linnane, Phil Robinson, Sarath Ranganathan, Stephen Stick, Conor Murray, Role of high-resolution computed tomography in the detection of early cystic fibrosis lung disease, Paediatric Respiratory Reviews, 2008, 9, 3, 168

    CrossRef

  17. 17
    S.G. McKenzie, S. Chowdhury, B. Strandvik, M.E. Hodson, Dornase alfa is well tolerated: Data from the Epidemiologic Registry of Cystic Fibrosis, Pediatric Pulmonology, 2007, 42, 10
    Direct Link:
  18. 18
    Terry E. Robinson, Imaging of the Chest in Cystic Fibrosis, Clinics in Chest Medicine, 2007, 28, 2, 405

    CrossRef

  19. 19
    Harm A.W.M. Tiddens, Chest computed tomography scans should be considered as a routine investigation in cystic fibrosis, Paediatric Respiratory Reviews, 2006, 7, 3, 202

    CrossRef

  20. 20
    Samya Z. Nasr, Diane Gordon, Ermelinda Sakmar, Xin Yu, Emmanuel Christodoulou, Boris P. Eckhardt, Peter J. Strouse, High resolution computerized tomography of the chest and pulmonary function testing in evaluating the effect of tobramycin solution for inhalation in cystic fibrosis patients, Pediatric Pulmonology, 2006, 41, 12
    Direct Link:
  21. 21
    Harm AWM Tiddens, Pim A de Jong, Update on the application of chest computed tomography scanning to cystic fibrosis, Current Opinion in Pulmonary Medicine, 2006, 12, 6, 433

    CrossRef

  22. 22
    Frederick R. Long, Roger S. Williams, Brent H. Adler, Robert G. Castile, Comparison of quiet breathing and controlled ventilation in the high-resolution CT assessment of airway disease in infants with cystic fibrosis, Pediatric Radiology, 2005, 35, 11, 1075

    CrossRef

  23. 23
    Samuel M. Moskowitz, Ronald L. Gibson, Eric L. Effmann, Cystic fibrosis lung disease: genetic influences, microbial interactions, and radiological assessment, Pediatric Radiology, 2005, 35, 8, 739

    CrossRef

  24. 24
    Steven P Conway, Daniel G Peckham, Miles Denton, Keith, G Brownlee, Optimizing treatment policies and improving care: impact on outcome in patients with cystic fibrosis, Expert Review of Pharmacoeconomics & Outcomes Research, 2005, 5, 6, 791

    CrossRef

  25. 25
    Ranjan Suri, The Use of Human Deoxyribonuclease (rhDNase) in the Management of Cystic Fibrosis, BioDrugs, 2005, 19, 3, 135

    CrossRef

  26. 26
    Terry E Robinson, High-resolution CT scanning: potential outcome measure, Current Opinion in Pulmonary Medicine, 2004, 10, 6, 537

    CrossRef

  27. 27
    Suzanne Terheggen-Lagro, Neeltje Truijens, Noor van Poppel, Vincent Gulmans, Johan van der Laag, Cornelis van der Ent, Correlation of six different cystic fibrosis chest radiograph scoring systems with clinical parameters, Pediatric Pulmonology, 2003, 35, 6
    Direct Link:
  28. 28
    Maartje ten Berge, Els van der Wiel, Harm A.W.M. Tiddens, Peter J.F.M. Merkus, Wim C.J. Hop, Johan C. de Jongste, DNase in stable cystic fibrosis infants: a pilot study, Journal of Cystic Fibrosis, 2003, 2, 4, 183

    CrossRef

  29. 29
    Peter J.F.M Merkus, Effects of childhood respiratory diseases on the anatomical and functional development of the respiratory system, Paediatric Respiratory Reviews, 2003, 4, 1, 28

    CrossRef

  30. 30
    E.A. Edwards, R. Metcalfe, D.G. Milne, J. Thompson, C.A. Byrnes, Retrospective review of children presenting with non cystic fibrosis bronchiectasis: HRCT features and clinical relationships, Pediatric Pulmonology, 2003, 36, 2
    Direct Link:
  31. 31
    P. Le Roux, B. Le Luyer, Traitements inhales bronchodilatateurs et fluidifiants dans la mucoviscidose, Archives de Pédiatrie, 2003, 10, S358

    CrossRef

  32. 32
    Ashley P Jones, Colin Wallis, Dornase alfa for cystic fibrosis, The Cochrane Library,
    Direct Link:
  33. 33
    Ashley P Jones, Colin Wallis, Catherine E Kearney, Dornase alfa for cystic fibrosis, The Cochrane Library,
    Direct Link:
  34. 34
    Ruth Dentice, Mark Elkins, Timing of dornase alfa inhalation for cystic fibrosis, The Cochrane Library,
    Direct Link:
Get PDF (150K)