Previously presented at the 106th American Society of Microbiology General Meeting, Orlando, 2006
Systemic cytokine profile in children with community-acquired pneumonia†
Article first published online: 29 MAY 2007
Copyright © 2007 Wiley-Liss, Inc.
Volume 42, Issue 7, pages 640–645, July 2007
How to Cite
Michelow, I. C., Katz, K., McCracken, G. H. and Hardy, R. D. (2007), Systemic cytokine profile in children with community-acquired pneumonia. Pediatr. Pulmonol., 42: 640–645. doi: 10.1002/ppul.20633
- Issue published online: 29 MAY 2007
- Article first published online: 29 MAY 2007
- Manuscript Accepted: 17 MAR 2007
- Manuscript Revised: 16 MAR 2007
- Manuscript Received: 9 OCT 2006
- NIH. Grant Number: K08 AI052262
- Mycoplasma pneumoniae;
- Streptococcus pneumoniae;
Characterization of the systemic cytokine response in community-acquired pneumonia (CAP) may facilitate our understanding of the host immune response and provide a prognostic as well as diagnostic tool. Systemic cytokine characterization of CAP has been limited largely to a few integral cytokines in adults.
Analyses were performed to investigate whether significant relationships existed between an expanded serum cytokine profile and etiologies, manifestations, and outcomes of pediatric CAP. The serum concentrations of 15 cytokines were investigated in 55 hospitalized children with well-characterized CAP.
Comparison of median cytokine concentrations among patients with CAP caused by Mycoplasma pneumoniae or Chlamydophila pneumoniae, Streptococcus pneumoniae, viruses, mixed infections, or unidentified pathogens revealed significant differences in IFN-α, IL-6, IL-17, GM-CSF, and TNF-α concentrations. The mixed infections category had significantly elevated concentrations of IFN-α, IL-6, GM-CSF, and TNF-α. There were significant correlations between concentrations of IL-6 and markers of disease severity (white blood cell band-forms, procalcitonin, and unequivocal consolidation). No single cytokine could reliably differentiate the etiologic cause of pneumonia.
IL-6 is the only one of 15 serum cytokines studied that correlated with indicators of disease severity in childhood CAP. The applicability of cytokine profiles to identify microbiologic etiologies of pneumonia remains to be defined. Pediatr Pulmonol. 2007; 42:640–645. © 2007 Wiley-Liss, inc.