Hans Bisgaard has been a consultant to, paid lecturer for, and holds sponsored grants from, Aerocrine, AstraZeneca, Altana, GSK, MedImmune and Merck. He has no stock ownership or commercial royalties in the respiratory field.
Article first published online: 27 JUN 2007
Copyright © 2007 Wiley-Liss, Inc.
Volume 42, Issue 8, pages 723–728, August 2007
How to Cite
Bisgaard, H. and Szefler, S. (2007), Prevalence of asthma-like symptoms in young children. Pediatr. Pulmonol., 42: 723–728. doi: 10.1002/ppul.20644
Stanley Szefler has Served as a consultant and member of an advisory board for GSK, AstraZeneca and Aventis for the past 3 years and for Merck for the past 2 years. He has received research funds for clinical trial performance from AstraZeneca and Ross. He has no stock ownership or commercial royalties in any of these companies.
- Issue published online: 27 JUN 2007
- Article first published online: 27 JUN 2007
- Manuscript Accepted: 16 APR 2007
- Manuscript Revised: 9 APR 2007
- Manuscript Received: 20 NOV 2006
- AstraZeneca R&D, Lund, Sweden
- preschool children;
- respiratory symptoms;
- respiratory infectious diseases;
To determine the prevalence, impact, and treatment of asthma-like symptoms in preschool children in USA and Europe.
7251 households in USA and Europe with at least one child aged 1–5 years were interviewed by telephone for recurrent days troubled by cough, wheeze or breathlessness during the recent 6 winter months.
9490 young children were identified, 32% of whom were reported to suffer from recurrent days with troublesome cough, wheeze or breathlessness. Detailed interview with the 2700 mothers of the symptomatic children showed that 24% of this interview population suffered weekly symptoms despite current treatment with considerable impact on lifestyle and healthcare resource use. Antibiotics, cough- and herbal-medications were the most commonly used treatments. Anti-asthmatic and anti-allergy agents were prescribed in the order: inhaled β2-agonists > inhaled corticosteroid > oral anti-histamines > oral corticosteroids. The reported symptom burden was higher in Southern Europe and there were pronounced regional differences in treatment and diagnostic terms.
Recurrent days with cough, wheeze or breathlessness in preschool children represents a major cause of morbidity in preschool children despite current treatment. There is a striking lack of international consensus on diagnosis and treatment. This uncontrolled morbidity highlights a significant unmet clinical need in preschool children. Pediatr Pulmonol. 2007, 42:723–728. © 2007 Wiley-Liss, Inc.