The authors state that no financial assistance was received in support of the study.
Superoxide dismutase and catalase activity in naturally derived commercial surfactants†
Article first published online: 14 OCT 2009
Copyright © 2009 Wiley-Liss, Inc.
Volume 44, Issue 11, pages 1125–1131, November 2009
How to Cite
Dani, C., Buonocore, G., Longini, M., Felici, C., Rodriguez, A., Corsini, I. and Rubaltelli, F. F. (2009), Superoxide dismutase and catalase activity in naturally derived commercial surfactants. Pediatr. Pulmonol., 44: 1125–1131. doi: 10.1002/ppul.21116
- Issue published online: 23 OCT 2009
- Article first published online: 14 OCT 2009
- Manuscript Revised: 3 JUN 2009
- Manuscript Accepted: 3 JUN 2009
- Manuscript Received: 7 FEB 2009
- reactive oxygen species;
- hydrogen peroxide;
- superoxide dismutase;
Despite the role of reactive oxygen species in the development of respiratory distress syndrome (RDS) and bronchopulmonary dysplasia (BPD) in preterm infants, the anti-oxidant properties of commercial surfactants have never been studied. We measured the superoxide dismutase (SOD) and catalase (CAT) activity, the scavenger activity against hydrogen peroxide (H2O2), and its changes after the addition of SOD and CAT in four natural surfactants, namely Infasurf, Curosurf, Survanta, and Alveofact. We found that they contain measurable amount of SOD and CAT. Curosurf and Survanta seem to have higher antioxidant effect than Infasurf and Alveofact. Moreover, the highest phospholipid concentration and recommended dose of Curosurf imply that its scavenger activity for each treatment dose in preterm infants is likely higher than that of Survanta. Finally, the supplementation with SOD and CAT induced a remarkable increase of antioxidant action in all studied surfactants. Pediatr Pulmonol. 2009; 44:1125–1131. ©2009 Wiley-Liss, Inc.