Conflict of interest: None.
Original Article: Asthma
Article first published online: 29 MAY 2012
Copyright © 2012 Wiley Periodicals, Inc.
Volume 47, Issue 12, pages 1170–1179, December 2012
How to Cite
Rikkers-Mutsaerts, E.R.V.M., Winters, A.E., Bakker, M.J., van Stel, H.F., van der Meer, V., de Jongste, J.C., Sont, J.K. and the SMASHING Study Group (2012), Internet-based self-management compared with usual care in adolescents with asthma: A randomized controlled trial. Pediatr. Pulmonol., 47: 1170–1179. doi: 10.1002/ppul.22575
Trial Registration: Smashing in adolescents, International Standard Randomized Controlled Trial number: ISRCTN 11633371.
- Issue published online: 15 NOV 2012
- Article first published online: 29 MAY 2012
- Manuscript Accepted: 12 MAR 2012
- Manuscript Received: 17 OCT 2011
- Netherlands Asthma Foundation. Grant Numbers: 3.4.03.157, 3.4.03.45
- quality of life;
Asthma control often is poor in adolescents and this causes considerable morbidity. Internet-based self-management (IBSM) improves asthma-related quality of life in adults. We hypothesized that IBSM improves asthma-related quality of life in adolescents.
Adolescents (12–18 years) with persistent and not well-controlled asthma participated in a randomized controlled trial with 1 year follow-up and were allocated to IBSM (n = 46) or usual care (UC, n = 44). IBSM consisted of weekly asthma control monitoring with treatment advice by a web-based algorithm. Outcomes included asthma-related quality of life (Pediatric Asthma Quality of Life Questionnaire, PAQLQ) and asthma control (Asthma Control Questionnaire, ACQ) and were analyzed by a linear mixed-effects model.
At 3 months, PAQLQ improved with 0.40 points (95% CI: 0.17–0.62, P < 0.01), by IBSM compared to 0.0 points for UC (P = 0.02 for the difference). At 12 months the between-group difference was −0.05 (95% CI: −0.50 to 0.41, P = 0.85). At 3 months ACQ improved more in IBSM than in UC (difference: −0.32 points; 95% CI: −0.56 to −0.079, P < 0.01). At 12 months the difference was −0.05 (95% CI: −0.35 to 0.25, P = 0.75).
IBSM improved asthma-related quality of life and asthma control in adolescents with not well-controlled asthma after 3 months, but not after 12 months. Pediatr Pulmonol. 2012; 47:1170–1179. © 2012 Wiley Periodicals, Inc.