Conflict of interest: None.
Original Article: Epidemiology
Waist circumference, BMI, and lung function in 8-year-old children: The PIAMA birth cohort study†
Version of Record online: 9 NOV 2012
Copyright © 2012 Wiley Periodicals, Inc.
Volume 48, Issue 7, pages 674–682, July 2013
How to Cite
Bekkers, M. B.M., Wijga, A. H., de Jongste, J. C., Kerkhof, M., Postma, D., Gehring, U., Smit, H. A. and Brunekreef, B. (2013), Waist circumference, BMI, and lung function in 8-year-old children: The PIAMA birth cohort study. Pediatr. Pulmonol., 48: 674–682. doi: 10.1002/ppul.22722
- Issue online: 18 JUN 2013
- Version of Record online: 9 NOV 2012
- Manuscript Accepted: 3 OCT 2012
- Manuscript Received: 2 JAN 2012
- The Netherlands Organization for Health Research and Development
- The Netherlands Organization for Scientific Research
- The Netherlands Asthma Fund, The Netherlands Ministry of Spatial Planning Housing, and the Environment
- The Netherlands Ministry of Health, Welfare and Sport
Body mass index (BMI) and waist circumference (WC) may be associated with lung function in children, as observed in adults.
Height, weight, waist circumference, and lung function (FVC and FEV1) were measured during a medical examination in 1,058 eight-year-old children participating in the Prevention and Incidence of Asthma and Mite Allergy (PIAMA) birth cohort study.
After adjusting for height, age and other potential confounders large WC or high BMI (>90th percentile) were not associated with forced expiratory volume in 1 sec (FEV1) or forced vital capacity (FVC). In girls only, large WC was, independently of BMI, associated with 3.5% (95% confidence interval (CI): −6.4, −0.6) lower FEV1/FVC ratio in the model including WC and BMI. Girls with low BMI (<10th percentile) had 4.6% lower FEV1 (95% CI: −8.4, −0.6) and 5.1% lower FVC (95% CI: −8.8, −1.2) than girls with normal BMI. In boys, we did not observe associations between low or high BMI and lung function independent of WC, or between small or large WC and lung function after adjustment for BMI.
At 8 years of age, a high BMI or large WC are not yet associated with FEV1 and FVC, indicating that this association may change over the course of life from childhood to adulthood. Pediatr Pulmonol. 2013; 48:674–682. © 2012 Wiley Periodicals, Inc.