Financial Disclosures: Dr. Singleton conducted pneumococcal vaccine research sponsored by Pfizer Inc. in 2009–2010. Dr. Redding receives a stipend as Pulmonary Section Editor of UpToDate.
Indigenous children from three countries with non-cystic fibrosis chronic suppurative lung disease/bronchiectasis
Version of Record online: 8 FEB 2013
© 2013 Wiley Periodicals, Inc.
Volume 49, Issue 2, pages 189–200, February 2014
How to Cite
Singleton, R. J., Valery, P. C., Morris, P., Byrnes, C. A., Grimwood, K., Redding, G., Torzillo, P. J., McCallum, G., Chikoyak, L., Mobberly, C., Holman, R. C. and Chang, A. B. (2014), Indigenous children from three countries with non-cystic fibrosis chronic suppurative lung disease/bronchiectasis. Pediatr. Pulmonol., 49: 189–200. doi: 10.1002/ppul.22763
Conflict of interest: None.
- Issue online: 23 JAN 2014
- Version of Record online: 8 FEB 2013
- Manuscript Accepted: 13 DEC 2012
- Manuscript Received: 11 SEP 2012
- National Health and Medical Research Council of Australia (NHMRC). Grant Numbers: 389837, 1040830
- Telstra Foundation (seeding grant—Telstra Community Development Grant, 2004)
- Australian Research Council Future Fellowship. Grant Number: 100100511
- Australian NHMRC Fellowship. Grant Number: 545216
- Health Research Council of New Zealand. Grant Number: 08/158
- Asthma and Respiratory Foundation of New Zealand
- Auckland Medical Research Foundation, NZ. Grant Number: 81542
- National Institutes of Health, National Heart Lung and Blood Institute. Grant Number: U26IHS3000001/01
- indigenous population;
- chronic suppurative lung diseases;
Indigenous children in developed countries are at increased risk of chronic suppurative lung disease (CSLD), including bronchiectasis. We evaluated sociodemographic and medical factors in indigenous children with CSLD/bronchiectasis from Australia, United States (US), and New Zealand (NZ).
Indigenous children aged 0.5–8 years with CSLD/bronchiectasis were enrolled from specialist clinics in Australia (n = 97), Alaska (n = 41), and NZ (n = 42) during 2004–2009, and followed for 1–5 years. Research staff administered standardized parent interviews, reviewed medical histories and performed physical examinations at enrollment.
Study children in all three countries had poor housing and sociodemographic circumstances at enrollment. Except for increased household crowding, most poverty indices in study participants were similar to those reported for their respective local indigenous populations. However, compared to their local indigenous populations, study children were more often born prematurely and had both an increased frequency and earlier onset of acute lower respiratory infections (ALRIs). Most (95%) study participants had prior ALRI hospitalizations and 77% reported a chronic cough in the past year. Significant differences (wheeze, ear disease and plumbed water) between countries were present.
Indigenous children with CSLD/bronchiectasis from three developed countries experience significant disparities in poverty indices in common with their respective indigenous population; however, household crowding, prematurity and early ALRIs were more common in study children than their local indigenous population. Addressing equity, especially by preventing prematurity and ALRIs, should reduce risk of CSLD/bronchiectasis in indigenous children. Pediatr Pulmonol. 2014; 49:189–200. © 2013 Wiley Periodicals, Inc.