Tidal breathing FeNO measurements: A new algorithm
Article first published online: 8 FEB 2013
© 2013 Wiley Periodicals, Inc.
Volume 49, Issue 1, pages 15–20, January 2014
How to Cite
van Mastrigt, E., de Groot, R. C.A., van Kesteren, H. W., Vink, A. T.J., de Jongste, J. C. and Pijnenburg, M. W.H. (2014), Tidal breathing FeNO measurements: A new algorithm. Pediatr. Pulmonol., 49: 15–20. doi: 10.1002/ppul.22782
- Issue published online: 16 DEC 2013
- Article first published online: 8 FEB 2013
- Manuscript Revised: 22 DEC 2012
- Manuscript Accepted: 22 DEC 2012
- Manuscript Received: 9 AUG 2012
- Philips Research, the Netherlands
- exhalation flow;
- fractional exhaled nitric oxide;
- single breath;
- tidal breathing
International guidelines recommend measuring fractional exhaled nitric oxide (FeNO) during a single slow exhalation with a constant flow of 50 ml/sec. We developed a new algorithm to compute FeNO at 50 ml/sec from tidal breathing measurements. The main objective is to assess the correlation and agreement of this algorithm with the conventional single breath FeNO measurements.
We recruited children aged 6–18 years, who performed both a single breath and a tidal breathing FeNO measurement in random order. Both maneuvers were performed on the Eco Medics NO-analyser (Eco Physics AG, Duernten, Switzerland).
We included 109 patients between January 2011 and April 2011. Geometric mean (95% CI) FeNO values did not differ significantly between single breath and tidal breathing technique: 21.0 (17.7–24.8) ppb and 20.0 (17.0–23.6) ppb (P = 0.18), respectively. We found an excellent intraclass correlation coefficient of 0.96 (0.94–0.97) and moderate agreement with a mean difference of 4% (95% limits of agreement −43% and +90%).
Tidal breathing FeNO values could be transformed with a new algorithm to match single breath FeNO at a constant flow of 50 ml/sec. This algorithm opens the way to standardized FeNO measurements in preschool children and uncooperative patients. Pediatr Pulmonol. 2014; 49:15–20. © 2013 Wiley Periodicals, Inc.