Synthese von Substanz P und acylierten Teilsequenzen

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Abstract

Synthesis of Substance P and of Acylated Partial Sequences

Substance P undecapeptide has been synthesized by the stepwise procedure and via condensation of the fragments 1–4 and 5–11. Formation of pyrrolidone carboxylic acid- and S-tert. butyl peptides was observed. Gln(Mbh)-containing sequences have been synthesized but were not useful for fragment condensation due to there low solubility. Additionally, some derivatives have been prepared by acylation of the C-terminal pentapeptide. Reaction with trifluoracetic acid anhydride resulted in the formation of substituted 5-amino-oxazole derivatives as detected by mass spectrometric investigation.

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