Synthesis of Schizokinen, Homoschizokinen, Its Imide and the detection of imide with 13C-N.M.R.-spectroscopy

Authors

  • Dr. Maria J. Milewska,

    Corresponding author
    1. Department of Organic Chemistry, Technical University of Gdansk, PL 80-952 Gdansk 6, Poland
    • Department of Organic Chemistry, Technical University of Gdansk, PL 80-952 Gdansk 6, Poland
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  • Prof. Andrzej Chimiak,

    1. Department of Organic Chemistry, Technical University of Gdansk, PL 80-952 Gdansk 6, Poland
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  • Mgr. Zdzisław Głowacki

    1. Department of Organic Chemistry, Technical University of Gdansk, PL 80-952 Gdansk 6, Poland
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  • This work was supported by Grants CPBR 3.13.6 and CPBP 01.13.2.6

Abstract

A new method for the synthesis of homoschizokinen 1 and schizokinen 2 is described. 2-tert-Butyl-1,3-di-N-hydroxysuccinimidyl citrate has been applied as the key substrate. The method excludes the possibility of imide formation. The imide of compound 1 has been obtained analogously from the active ester of the 1,3-dioxolan-4-one derivative 5. It has been stated that 13C-n.m.r. signals of the C-3 carbon atoms enable the detection of traces of homoschizokinen 17.

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