Review

Cardiac myofilaments: from proteome to pathophysiology

  1. Wenhai Jin1,
  2. Anna T. Brown2,
  3. Anne M. Murphy Dr.1,*

Article first published online: 12 JUN 2008

DOI: 10.1002/prca.200780075

Issue

PROTEOMICS - Clinical Applications

PROTEOMICS - Clinical Applications

Special Issue: CARDIOVASCULAR PROTEOMICS

Volume 2, Issue 6, pages 800–810, No. 6 June 2008

Additional Information

How to Cite

Jin, W., Brown, A. T. and Murphy, A. M. (2008), Cardiac myofilaments: from proteome to pathophysiology. Prot. Clin. Appl., 2: 800–810. doi: 10.1002/prca.200780075

Author Information

  1. 1

    Departments of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA

  2. 2

    Anesthesia and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA

*Departments of Pediatrics, Johns Hopkins University School of Medicine, Ross Building 1144, 720 Rutland Avenue, Baltimore, MD 21205, USA Fax: +1-410-614-0699

Publication History

  1. Issue published online: 12 JUN 2008
  2. Article first published online: 12 JUN 2008
  3. Manuscript Received: 1 OCT 2007

Funded by

  • NIH. Grant Numbers: N01-HV-28180, R01-HL-63038

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Keywords:

  • Cardiac ischemia;
  • Heart failure;
  • Myofilament;
  • Post-translational modification

Abstract

This review addresses the functional consequences of altered post-translational modifications of cardiac myofilament proteins in cardiac diseases such as heart failure and ischemia. The modifications of thick and thin filament proteins as well as titin are addressed. Understanding the functional consequences of altered protein modifications is an essential step in the development of targeted therapies for common cardiac diseases.

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