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Review
Nitric oxide-mediated protein modification in cardiovascular physiology and pathology
Article first published online: 12 JUN 2008
DOI: 10.1002/prca.200780079
Copyright © 2008 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Issue
PROTEOMICS - Clinical Applications
Special Issue: CARDIOVASCULAR PROTEOMICS
Volume 2, Issue 6, pages 811–822, No. 6 June 2008
Additional Information
How to Cite
Gödecke, A., Schrader, J. and Reinartz, M. (2008), Nitric oxide-mediated protein modification in cardiovascular physiology and pathology. Prot. Clin. Appl., 2: 811–822. doi: 10.1002/prca.200780079
Publication History
- Issue published online: 12 JUN 2008
- Article first published online: 12 JUN 2008
- Manuscript Received: 10 OCT 2007
Funded by
- Deutsche Forschungsgemeinschaft (DFG). Grant Numbers: SFB612 TP A5 and B6, GRK1089 TP2 and TP6
- Abstract
- References
- Cited By
Keywords:
- Heart;
- Nitric oxide;
- S-nitrosation;
- Tyrosine nitration
Abstract
Nitric oxide (NO) is a key regulator of cardiovascular functions including the control of vascular tone, anti-inflammatory properties of the endothelium, cardiac contractility, and thrombocyte activation and aggregation. Numerous experimental data support the view that NO not only acts via cyclic guanosine monophosphate (cGMP)-dependent mechanisms but also modulates protein function by nitrosation, nitrosylation, glutathiolation, and nitration, respectively. To understand how NO regulates all of these diverse biological processes on the molecular level a comprehensive assessment of NO-mediated cGMP-dependent and independent targets is required. Novel proteomic approaches allow the simultaneous identification of large quantities of proteins modified in an NO-dependent manner and thereby will considerably deepen our understanding of the role NO plays in cardiovascular physiology and pathophysiology.