Review

You have free access to this content

Proteomic insights into cardiac cell death and survival

  1. W. Robb MacLellan1,2,
  2. Yibin Wang1,2,3,
  3. Thomas M. Vondriska1,2,3,
  4. James N. Weiss1,2,
  5. Peipei Ping Professor1,2,*

Article first published online: 12 JUN 2008

DOI: 10.1002/prca.200780121

Issue

PROTEOMICS - Clinical Applications

PROTEOMICS - Clinical Applications

Special Issue: CARDIOVASCULAR PROTEOMICS

Volume 2, Issue 6, pages 837–844, No. 6 June 2008

Additional Information

How to Cite

MacLellan, W. R., Wang, Y., Vondriska, T. M., Weiss, J. N. and Ping, P. (2008), Proteomic insights into cardiac cell death and survival. Prot. Clin. Appl., 2: 837–844. doi: 10.1002/prca.200780121

Author Information

  1. 1

    Department of Medicine/Cardiology, Cardiovascular Research Laboratories, University of California, Los Angeles, CA, USA

  2. 2

    Department of Physiology, Cardiovascular Research Laboratories, University of California, Los Angeles, CA, USA

  3. 3

    Department of Anesthesiology, Cardiovascular Research Laboratories, University of California, Los Angeles, CA, USA

*Departments of Physiology and Medicine, David Geffen School of Medicine at UCLA, Suite 1609 MRL Building, Los Angles, CA 90095, USA Fax: +1-310-267-5623

Publication History

  1. Issue published online: 12 JUN 2008
  2. Article first published online: 12 JUN 2008
  3. Manuscript Received: 16 NOV 2007

Funded by

  • National Heart, Lung and Blood Institute of the National Institutes of Health
  • University of California, Los Angeles

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

Get PDF (238K)

Keywords:

  • Cardiovascular disease;
  • Heart;
  • Mitochondria;
  • Proteasome;
  • Signal transduction

Abstract

Cardiovascular disease is the leading cause of death and disability in the developed world. To design novel therapeutic strategies to treat and prevent this disease, better understanding of cardiac cell function is necessary. In addition to (and, indeed, in combination with) genetics, physiology and molecular biology, proteomics plays a critical role in our understanding of cardiovascular systems at multiple scales. The purpose of this review is to examine recent developments in the field of myocardial injury and protection, examining how proteomics has informed investigations into organelles, signaling complexes, and cardiac phenotype.

Get PDF (238K)