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Proteomic analysis of secretory proteins and vesicles in vascular research

  1. Giordano Pula1,
  2. Sue Perera2,
  3. Marianna Prokopi1,
  4. Anissa Sidibe1,
  5. Chantal M. Boulanger3,
  6. Manuel Mayr Dr.1,*

Article first published online: 12 JUN 2008

DOI: 10.1002/prca.200800040

Issue

PROTEOMICS - Clinical Applications

PROTEOMICS - Clinical Applications

Special Issue: CARDIOVASCULAR PROTEOMICS

Volume 2, Issue 6, pages 882–891, No. 6 June 2008

Additional Information

How to Cite

Pula, G., Perera, S., Prokopi, M., Sidibe, A., Boulanger, C. M. and Mayr, M. (2008), Proteomic analysis of secretory proteins and vesicles in vascular research. Prot. Clin. Appl., 2: 882–891. doi: 10.1002/prca.200800040

Author Information

  1. 1

    Cardiovascular Division, King's College London, London, UK

  2. 2

    Randall Division of Cell and Molecular Biophysics, King's College London, London, UK

  3. 3

    INSERM Cardiovascular Research Center Lariboisière, Paris, France

*Cardiovascular Division, The James Black Centre, King's College London, 125 Coldharbour Lane, London SE5 9NU, UK Fax: +44-20-7848-5296

Publication History

  1. Issue published online: 12 JUN 2008
  2. Article first published online: 12 JUN 2008
  3. Manuscript Received: 8 FEB 2008

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Keywords:

  • Atherosclerosis;
  • Cardiovascular;
  • Microparticles;
  • Secretory proteins

Abstract

The release of proteins and membrane vesicles in the bloodstream regulates diverse vascular processes, both physiological, such as angiogenesis and haemostasis, and pathological, such as atherosclerosis and atherothrombosis. Proteomics, beside its canonical application for the expression profiling in cells and organs, can be applied to the study of secreted proteins and microvesicles, which play a significant role in the homeostasis of the vasculature, and the development of the atherosclerotic disease.

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