Biomarkers in pediatrics: Children as biomarker orphans

Authors

  • William J. Savage,

    Corresponding author
    1. Divisions of Transfusion Medicine and Pediatric Hematology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    • Carnegie 667, 600 N. Wolfe Str. Baltimore, MD 21287, USA Fax: +1-410-955-0618
    Search for more papers by this author
  • Allen D. Everett

    1. Division of Pediatric Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Search for more papers by this author

Abstract

Biomarkers have enormous potential to improve patient care by establishing tests of diagnosis, prognosis, and treatment effects. Successfully translating a biomarker from discovery to clinical application demands high-quality discovery research and high-quality clinical studies for biomarker validation; however, there are additional challenges that face biomarker research in pediatrics. There are also additional characteristics of pediatric medicine that make biomarker research especially needed. This review focuses on the fundamentals of biomarkers, the additional considerations needed for applying biomarker research to children, and recommendations for advancing pediatric biomarker research.

Ancillary