Get access

Developing proteomics-based biomarkers for colorectal neoplasms for clinical practice: Opportunities and challenges

Authors

  • Yanxin Luo,

    1. Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, P. R. China
    2. Gastrointestinal Institute, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, P. R. China
    3. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Search for more papers by this author
  • Lei Wang,

    Corresponding author
    1. Gastrointestinal Institute, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, P. R. China
    • Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, P. R. China
    Search for more papers by this author
  • Jianping Wang

    Corresponding author
    1. Gastrointestinal Institute, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, P. R. China
    • Department of Colorectal Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, P. R. China
    Search for more papers by this author

Correspondence: Dr. Jianping Wang, Department of Colorectal Surgery, The Sixth Affiliated Hospital of Sun Yat-sen University, Yuancun Erheng Road, Guangzhou 510655, P. R. China

E-mail: wangjply@yahoo.com.cn

Fax: +86-20-3825-4221

Additional corresponding author: Dr. Lei Wang

E-mail: leiwangyinghu@yahoo.com.cn

Abstract

Colorectal cancer (CRC) arises from the normal colon epithelium through the accumulation of genetic mutations and epigenetic alterations that are associated with progression along the histological adenoma-adenocarcinoma sequence. Elucidating the molecular alterations underlying disease progression will not only provide insight into the behavior of the tumors, but also could lead to the discovery of useful biomarkers for diagnosis, monitoring treatment responsiveness, or predicting disease outcomes. In the past a few years, there have been several evaluating differentially expressed protein biomarkers by employing proteomics technologies coupled with mass spectrometry. In the current review, we will briefly summarize the results from selected recent studies using tissue or serum samples from CRC patients in the past 5 years and discuss the opportunities and challenges in translating these findings from the research setting to clinical practice.

Get access to the full text of this article

Ancillary