Current address: Centre for Cancer Research, Mouse Cancer Genetics Program, National Cancer Institute Frederick, MD, USA.
Prognostic utility of autoantibodies to α-enolase and Hsp70 for cancer of the gingivo-buccal complex using immunoproteomics
Article first published online: 1 MAR 2013
© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PROTEOMICS - Clinical Applications
Special Issue: Focus on Cancer Proteomics
Volume 7, Issue 5-6, pages 392–402, June 2013
How to Cite
Pranay, A., Shukla, S., Kannan, S., Malgundkar, S. A., Govekar, R. B., Patil, A., Kane, S. V., Chaturvedi, P., D'Cruz, A. K. and Zingde, S. M. (2013), Prognostic utility of autoantibodies to α-enolase and Hsp70 for cancer of the gingivo-buccal complex using immunoproteomics. Prot. Clin. Appl., 7: 392–402. doi: 10.1002/prca.201200081
- Issue published online: 18 JUN 2013
- Article first published online: 1 MAR 2013
- Accepted manuscript online: 17 NOV 2012 05:54AM EST
- Manuscript Accepted: 26 OCT 2012
- Manuscript Revised: 11 OCT 2012
- Manuscript Received: 9 AUG 2012
- Council of Scientific and Industrial Research. Grant Number: 27(0151)/06/EMR-II
- Lady Tata Memorial Trust
- Oral cancer;
Studies from our laboratory have reported 14 tumor antigens that elicit an autoantibody response in patients with cancer of the gingivobuccal complex (GBC) In this study, utility of the autoantibody response has been evaluated for prognosis of cancer of the GBC.
Autoantibody response was evaluated using immunoproteomics and the prognostic significance was assessed by Kaplan-Meier survival and multivariate analysis.
Autoantibody response against α-enolase isoforms a, b, and c and Hsp70 was detected in 27, 53, 64, and 26% of the 78 patients, respectively. Patients positive for autoantibody response to α-ENO and Hsp70 individually and in combination, showed significantly reduced disease-free survival (DFS) compared to those who do not show autoantibody response to either of them. Further the patients, who exhibit autoantibody response to α-ENO and Hsp70 in combination with nodal involvement and/or differentiation status, have significantly lowered DFS. The relative risk of recurrence is 3.41 for patients who exhibit autoantibody response to both the antigens.
Conclusions and clinical relevance
Autoantibody response against α-ENO and Hsp70 provides an additional parameter and may be utilized along with nodal involvement and differentiation status for better prognosis of cancer of GBC.