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Figures S1 (A–L) ; Representative autographs of 2DE blots of KB lysates probed with IgG purified from sera of patients with cancer of GBC and normal healthy individuals. Position of the signals for alpha enolase a, b and c (marked a, b, c), Hsp 70 and some of the other antigens are shown with red arrows. The same signals are not found in autographs probed with IgG from sera of normal healthy controls as shown in Fig. (K, L). The numbers written on the top left are the sample numbers of the patients with cancer of GBC. CL22 and CL 45 are the blots for the control samples.

Figures S2 (A–J); Kaplan-Meier curves with univariate analysis for correlation of cumulative survival and DFS (in months) with autoantibody response in groups of patients negative for autoantibody response to each of the antigens shown and those positive for the response. A) Peroxiredoxin 6 (Prdx 6); B) Annexin 2 (Anx 2); C) ATP synthase (Atps); D) Pyruvate kinase (PKm); E) alpha tubulin (α tub); and F) beta tubulin (ß tub); G) aldose keto reductase 1 (AR 1); H) aldose keto reductase 2 (AR 2); I) phosphoglycerate mutase (Pgm); J) TPI. The number of patients in each group is given as (N) against each curve

Figure S3. Kaplan-Meier curves for correlation of cumulative survival and DFS (in months) in A) patients with and without nodal involvement, (node +ve and node –ve; B) patients with WD, moderately differentiated (MD) and poorly differentiated (PD) tumors. The number of patients in each group is given as (N) against each curve.

Table S1: Clinical information and autoantibody response to tumor antigens in patients with cancer of GBC

Table S2: Clinical information and autoantibody response to tumor antigens in healthy individuals

Table S3: Autoantibody response to identified tumor antigens in patients with cancer of GBC and normal healthy individuals.

Table S4: Correlation of autoantibody response to ɑ enolase and Hsp70 with clinicopathological parameters in patients with GBC cancer

Table S5: Correlation of autoantibody response to other tumor antigens with clinicopathological parameters of patients with cancer of GBC

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