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Glycated proteome: From reaction to intervention
Article first published online: 22 JAN 2013
© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PROTEOMICS - Clinical Applications
Special Issue: REVIEWS 2013
Volume 7, Issue 1-2, pages 155–170, January 2013
How to Cite
Kulkarni, M. J., Korwar, A. M., Mary, S., Bhonsle, H. S. and Giri, A. P. (2013), Glycated proteome: From reaction to intervention. Prot. Clin. Appl., 7: 155–170. doi: 10.1002/prca.201200101
- Issue published online: 22 JAN 2013
- Article first published online: 22 JAN 2013
- Accepted manuscript online: 26 NOV 2012 12:45PM EST
- Manuscript Accepted: 13 NOV 2012
- Manuscript Revised: 12 NOV 2012
- Manuscript Received: 31 AUG 2012
Glycation, a nonenzymatic reaction between reducing sugars and proteins, is a proteome wide phenomenon, predominantly observed in diabetes due to hyperglycemia. Glycated proteome of plasma, kidney, lens, and brain are implicated in the pathogenesis of various diseases, including diabetic complications, neurodegenerative diseases, cancer, and aging. This review discusses the strategies to characterize protein glycation, its functional implications in different diseases, and intervention strategies to protect the deleterious effects of protein glycation.