Oxidatively modified ApoA1: The left-hand side of the figure depicts an HDL particle with bound ApoA1 that has not undergone oxidative damage, and as shown, is able to function normally interacting with LCAT, peripheral ABCA1 and SRB-1. The righthand side of the figure displays an HDL particle that has undergone extensive oxidative modification on ApoA1, a process that has been shown to negatively affect the ability of the HDL particle to interact peripherally with ABCA1, LCAT, and SRB-1. This loss of function of ApoA1 has many consequences such as impaired ABCA1 signaling and cholesterol deposition to HDL, impaired cholesterol to cholesteryl conversion by LCAT, and the inability to dock with SRB-1.
For further details see article in this issue by Jeriel Keeney et al., Apolipoprotein A-I: Insights from redox proteomics for its role in neurodegeneration, Proteomics Clin. Appl. 2013, 7, 109-122 (DOI: 10.1002/prca.201200087).
Cover image created by Jeriel Keeney and Aaron Swomley (Prof. D. Allan Butterfield Group, Chemistry Department, University of Kentucky, Lexington. KY, USA); cover design by SCHULZ Grafik-Design.