Cover Picture: Proteomics 9-10'13


Cover Image: Foreground image taken from Tongzhong Ju et al., (pp. 618–631): IgA1 has normalO-glycans with a core 1 O-glycan decorated with sialic acids (purple diamonds) in either mono- or disiaylated structures. But in IgA1 from IgA nephropathy (IgAN) patients it is proposed that Tn and STn antigens lacking the core 1 O-glycan accumulate and contribute to IgAN. IgAN is the most common glomerulonephritis and results in renal failure in 20–40% of patients over 25 years of age. Deposition of IgA1 in the glomerular mesangium is thought to drive the disease. Background image, kindly provided by Tongzhong Ju, Richard D. Cummings, et al.: Human primary colorectal adenocarcinoma cells highly express Tn antigen. A formalin fixed paraffin-embedded tissue section of human primary colorectal adenocarcinoma was immunohistochemically stained with anti-Tn monoclonal antibody (Red) and counter staining with Haemotoxylin (Blue). The tumor cells are highly stained with anti-TnmAb. Cover design by SCHULZGrafik-Design.