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Apolipoprotein AI tertiary structures determine stability and phospholipid-binding activity of discoidal high-density lipoprotein particles of different sizes

  1. Bin Chen1,†,
  2. Xuefeng Ren1,†,
  3. Tracey Neville2,
  4. W. Gray Jerome3,
  5. David W. Hoyt4,
  6. Daniel Sparks2,
  7. Gang Ren5,
  8. Jianjun Wang1,*

Article first published online: 16 MAR 2009

DOI: 10.1002/pro.101

Issue

Protein Science

Protein Science

Volume 18, Issue 5, pages 921–935, May 2009

Additional Information

How to Cite

Chen, B., Ren, X., Neville, T., Jerome, W. G., Hoyt, D. W., Sparks, D., Ren, G. and Wang, J. (2009), Apolipoprotein AI tertiary structures determine stability and phospholipid-binding activity of discoidal high-density lipoprotein particles of different sizes. Protein Science, 18: 921–935. doi: 10.1002/pro.101

Author Information

  1. 1

    Department of Biochemistry and Molecular Biology, School of Medicine, Wayne State University, Detroit, Michigan 48201

  2. 2

    Heart Institute, University of Ottawa, Ottawa, Ontario K1Y 4W7, Canada

  3. 3

    Department of Pathology, Vanderbilt University, Medical Center, Nashville, Tennessee 37232-2561

  4. 4

    Environmental Molecular Science Laboratory, Pacific Northwest, National Laboratories, Richland, Washington 99352

  5. 5

    Department of Biochemistry & Biophysics, University of California, San Francisco, California 94158

  1. †

    Bin Chen and Xuefeng Ren contributed equally to this work.

*Department of Biochemistry and Molecular Biology, School of Medicine, Wayne State University, Detroit, MI 48201

Publication History

  1. Issue published online: 21 APR 2009
  2. Article first published online: 16 MAR 2009
  3. Accepted manuscript online: 16 MAR 2009 12:00AM EST
  4. Manuscript Accepted: 26 FEB 2009
  5. Manuscript Revised: 25 FEB 2009
  6. Manuscript Received: 14 NOV 2008

Funded by

  • NIH (HDL International Research Award by Pfizer (to JW)). Grant Numbers: HL076620 (to JW), HL49148 (to WGJ)
  • The American Heart Association. Grant Number: AHA 0415063Z (to XR)
  • NIH. Grant Numbers: DK20539, CA68485, DK58404 (to Vanderbilt University EM facility)
  • The W.M. Keck Advanced Microscopy Laboratory, UCSF (to GR)

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