Protein Structure Report

You have full text access to this OnlineOpen article

Structural modification of acyl carrier protein by butyryl group

  1. Bai-Nan Wu1,
  2. Yong-Mei Zhang2,
  3. Charles O. Rock2,
  4. Jie J. Zheng1,3,*

Article first published online: 2 DEC 2008

DOI: 10.1002/pro.11

Issue

Protein Science

Protein Science

Volume 18, Issue 1, pages 240–246, January 2009

Additional Information

How to Cite

Wu, B.-N., Zhang, Y.-M., Rock, C. O. and Zheng, J. J. (2009), Structural modification of acyl carrier protein by butyryl group. Protein Science, 18: 240–246. doi: 10.1002/pro.11

Author Information

  1. 1

    Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105

  2. 2

    Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105

  3. 3

    Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163

*Department of Structural Biology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105

Publication History

  1. Issue published online: 16 DEC 2008
  2. Article first published online: 2 DEC 2008
  3. Accepted manuscript online: 2 DEC 2008 12:00AM EST
  4. Manuscript Accepted: 7 OCT 2008
  5. Manuscript Received: 18 JUL 2008

Funded by

  • American Lebanese Syrian Associated Charities
  • National Institutes of Heath

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (348K)

References

  • 1
    Rock CO,Jackowski S (2002) Forty years of bacterial fatty acid synthesis. Biochem Biophys Res Commun 292: 1155–1166.
  • 2
    White SW,Zheng J,Zhang YM,Rock CO (2005) The structural biology of type II fatty acid biosynthesis. Annu Rev Biochem 74: 791–831.
  • 3
    Anderson MS,Raetz CR (1987) Biosynthesis of lipid A precursors in Escherichia coli. A cytoplasmic acyltransferase that converts UDP- N-acetylglucosamine to UDP-3- O-(R-3-hydroxymyristoyl)- N-acetylglucosamine. J Biol Chem 262: 5159–5169.
  • 4
    Rock CO,Jackowski S (1982) Regulation of phospholipid synthesis in Escherichia coli. Composition of the acyl–acyl carrier protein pool in vivo. J Biol Chem 257: 10759–10765.
  • 5
    Issartel JP,Koronakis V,Hughes C (1991) Activation of Escherichia coli prohaemolysin to the mature toxin by acyl carrier protein-dependent fatty acylation. Nature 351: 759–761.
  • 6
    Flugel RS,Hwangbo Y,Lambalot RH,Cronan JE,Jr,Walsh CT (2000) Holo-(acyl carrier protein) synthase and phosphopantetheinyl transfer in Escherichia coli. J Biol Chem 275: 959–968.
  • 7
    Parris KD,Lin L,Tam A,Mathew R,Hixon J,Stahl M,Fritz CC,Seehra J,Somers WS (2000) Crystal structures of substrate binding to Bacillus subtilis holo-(acyl carrier protein) synthase reveal a novel trimeric arrangement of molecules resulting in three active sites. Structure Fold Des 8: 883–895.
  • 8
    Zhang YM,Wu B,Zheng J,Rock CO (2003) Key residues responsible for acyl carrier protein and beta-ketoacyl-acyl carrier protein reductase (FabG) interaction. J Biol Chem 278: 52935–52943.
  • 9
    Holak TA,Kearsley SK,Kim Y,Prestegard JH (1988) Three-dimensional structure of acyl carrier protein determined by NMR pseudoenergy and distance geometry calculations. Biochemistry 27: 6135–6142.
  • 10
    Kim Y,Prestegard JH (1989) A dynamic model for the structure of acyl carrier protein in solution. Biochemistry 28: 8792–8797.
  • 11
    Li Q,Khosla C,Puglisi JD,Liu CW (2003) Solution structure and backbone dynamics of the holo form of the frenolicin acyl carrier protein. Biochemistry 42: 4648–4657.
  • 12
    Wong HC,Liu G,Zhang YM,Rock CO,Zheng J (2002) The solution structure of acyl carrier protein from Mycobacterium tuberculosis. J Biol Chem 277: 15874–15880.
  • 13
    Xu GY,Tam A,Lin L,Hixon J,Fritz CC,Powers R (2001) Solution structure of B. subtilis acyl carrier protein. Structure 9: 277–287.
  • 14
    Roujeinikova A,Baldock C,Simon WJ,Gilroy J,Baker PJ,Stuitje AR,Rice DW,Slabas AR,Rafferty JB (2002) X-ray crystallographic studies on butyryl-ACP reveal flexibility of the structure around a putative acyl chain binding site. Structure 10: 825–835.
  • 15
    Crump MP,Crosby J,Dempsey CE,Parkinson JA,Murray M,Hopwood DA,Simpson TJ (1997) Solution structure of the actinorhodin polyketide synthase acyl carrier protein from Streptomyces coelicolor A3(2). Biochemistry 36: 6000–6008.
  • 16
    Weber T,Baumgartner R,Renner C,Marahiel MA,Holak TA (2000) Solution structure of PCP, a prototype for the peptidyl carrier domains of modular peptide synthetases. Structure Fold Des 8: 407–418.
  • 17
    Kim Y,Prestegard JH (1990) Refinement of the NMR structures for acyl carrier protein with scalar coupling data. Proteins 8: 377–385.
    Direct Link:
  • 18
    Grzesiek S,Bax A (1993) Amino acid type determination in the sequential assignment procedure of uniformly 13C/15N-enriched proteins. J Biomol NMR 3: 185–204.
  • 19
    Gronenborn AM,Clore GM (1995) Structures of protein complexes by multidimensional heteronuclear magnetic resonance spectroscopy. Crit Rev Biochem Mol Biol 30: 351–385.
  • 20
    Wong HC,Mao J,Nguyen JT,Srinivas S,Zhang W,Liu B,Li L,Wu D,Zheng J (2000) Structural basis of the recognition of the dishevelled DEP domain in the Wnt signaling pathway. Nat Struct Biol 7: 1178–1184.
  • 21
    Guntert P,Braun W,Wuthrich K (1991) Efficient computation of three-dimensional protein structures in solution from nuclear magnetic resonance data using the program DIANA and the supporting programs CALIBA, HABAS and GLOMSA. J Mol Biol 217: 517–530.
  • 22
    Laskowski RA,Rullmannn JA,MacArthur MW,Kaptein R,Thornton JM (1996) AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR. J Biomol NMR 8: 477–486.
  • 23
    Kyte J,Doolittle RF (1982) A simple method for displaying the hydropathic character of a protein. J Mol Biol 157: 105–132.
  • 24
    Pettersen EF,Goddard TD,Huang CC,Couch GS,Greenblatt DM,Meng EC,Ferrin TE (2004) UCSF Chimera—a visualization system for exploratory research and analysis. J Comput Chem 25: 1605–1612.
    Direct Link:
  • 25
    Sharma AK,Sharma SK,Surolia A,Surolia N,Sarma SP (2006) Solution structures of conformationally equilibrium forms of holo-acyl carrier protein (PfACP) from Plasmodium falciparum provides insight into the mechanism of activation of ACPs. Biochemistry 45: 6904–6916.
  • 26
    Zhang YM,Rao MS,Heath RJ,Price AC,Olson AJ,Rock CO,White SW (2001) Identification and analysis of the acyl carrier protein (ACP) docking site on beta-ketoacyl-ACP synthase III. J Biol Chem 276: 8231–8238.
  • 27
    Zhang YM,Marrakchi H,White SW,Rock CO (2003) The application of computational methods to explore the diversity and structure of bacterial fatty acid synthase. J Lipid Res 44: 1–10.
  • 28
    Koglin A,Mofid MR,Lohr F,Schafer B,Rogov VV,Blum MM,Mittag T,Marahiel MA,Bernhard F,Dotsch V (2006) Conformational switches modulate protein interactions in peptide antibiotic synthetases. Science 312: 273–276.
  • 29
    Delaglio F,Grzesiek S,Vuister GW,Zhu G,Pfeifer J,Bax A (1995) NMRPipe: a multidimensional spectral processing system based on UNIX pipes. J Biomol NMR 6: 277–293.
  • 30
    Xia T-H,Bartels C,Wuthrich K (1993) XEASY ETH automated spectroscopy for X window system user manual. Zurich: ETH-Honggerberg.
  • 31
    Goddard TD,Kneller DG (1998) SPARKY, 3.0. San Francisco: University of California.
  • 32
    Guntert P,Mumenthaler C,Wuthrich K (1997) Torsion angle dynamics for NMR structure calculation with the new program DYANA. J Mol Biol 273: 283–298.
View Full Article (HTML) Get PDF (348K)