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The Brichos domain of prosurfactant protein C can hold and fold a transmembrane segment
Article first published online: 30 MAR 2009
DOI: 10.1002/pro.123
Copyright © 2009 The Protein Society
Additional Information
How to Cite
Johansson, H., Eriksson, M., Nordling, K., Presto, J. and Johansson, J. (2009), The Brichos domain of prosurfactant protein C can hold and fold a transmembrane segment. Protein Science, 18: 1175–1182. doi: 10.1002/pro.123
Publication History
- Issue published online: 26 MAY 2009
- Article first published online: 30 MAR 2009
- Accepted manuscript online: 30 MAR 2009 12:00AM EST
- Manuscript Accepted: 23 MAR 2009
- Manuscript Revised: 16 MAR 2009
- Manuscript Received: 28 JAN 2009
Funded by
- Swedish Research Council. Grant Number: 10371
- Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning
References
- 1, , ( 2008) Biomimicry of surfactant protein C. Acc Chem Res 41: 1409–1417.
- 2, ( 2002) Hydrophobic surfactant proteins in lung function and disease. N Engl J Med 347: 2141–2148.
- 3, ( 2005) Surfactant protein C biosynthesis and its emerging role in conformational lung disease. Annu Rev Physiol 67: 663–696.
- 4, , , , , , ( 2008) Surfactant proteins B and C are both necessary for alveolar stability at end expiration in premature rabbits with respiratory distress syndrome. J Appl Phys 104: 1101–1108.
- 5, , ( 2004) Proteolytic generation and aggregation of peptides from transmembrane regions: lung surfactant protein C and amyloid β-peptide. Cell Mol Life Sci 61: 326–335.
- 6, , , , ( 1999) Amyloid fibril formation by pulmonary surfactant protein C. FEBS Lett 464: 138–142.
- 7, , ( 2007) Genetic disorders of surfactant proteins. Neonatology 91: 311–317.
- 8, , , , , , ( 2008) Mutations linked to interstitial lung disease can abrogate anti-amyloid function of prosurfactant protein C. Biochem J 41: 201–209.
- 9( 2005) Aspects on human amyloid forms and their fibril polypeptides. FEBS J 272: 5942–5949.Direct Link:
- 10, ( 2009) Crystallin proteins and amyloid fibrils. Cell Mol Life Sci 66: 62–81.
- 11( 2002) Protein misfolding, amyloid formation, and neurodegeneration. A critical role for molecular chaperones? Neuron 35: 9–12.
- 12, ( 2005) Modulation of neurodegeneration by molecular chaperones. Nat Rev 6: 11–22.
- 13, ( 2008) Hsp104, Hsp70 and Hsp40 interplay regulates formation, growth an elimination of Sup35 prions. EMBO J 27: 2712–2724.
- 14, ( 2008) Unraveling the mysteries of protein folding and misfolding. IUBMB Life 60: 769–774.Direct Link:
- 15, , , ( 2006) The Brichos domain-containing C-terminal part of pro-surfactant protein C binds to an unfolded poly-val transmembrane segment. J Biol Chem 281: 21032–21039.
- 16, , ( 2002) BRICHOS: a conserved domain in proteins associated with dementia, respiratory distress and cancer. Trends Biochem Sci 27: 329–332.
- 17, , ( 2005) Interaction between TFF1, a gastric tumor suppressor trefoil protein, and TFIZ1, a brichos domain-containing protein with homology to SP-C. Biochemistry 44: 7967–7975.
- 18, , , , , , ( 2008) C-terminal, endoplasmic reticulum-lumenal domain of prosurfactant protein C - structural features and membrane interactions. FEBS J 275: 536–547.Direct Link:
- 19, , ( 2007) Membrane chaperone Shr3 assists in folding amino acid permeases preventing precocious ERAD. J Cell Biol 176: 616–628.
- 20, , , , ( 2003) Deacylated pulmonary surfactant protein SP-C transforms from α-helical to amyloid fibril structure via a pH-dependent mechanism: an infrared structural investigation. Biophys J 85: 2417–2429.
- 21, , , ( 2001) The palmitoyl groups of lung surfactant protein C reduce unfolding into a fibrillogenic intermediate. J Mol Biol 310: 937–950.
- 22, , , , , , ( 2004) The N-terminal propeptide of lung surfactant protein C is necessary for biosynthesis and prevents unfolding of a metastable α-helix. J Mol Biol 338: 857–862.
- 23, , , , , , ( 2006) Structure and influence on stability and activity of the N-terminal propeptide part of lung surfactant protein C. FEBS J 273: 926–935.Direct Link:
- 24, , , , , ( 1998) Pulmonary surfactant-associated polypeptide C in a mixed organic solvent transforms from a monomeric α-helical state into insoluble β-sheet aggregates. Protein Sci 7: 2533–2540.Direct Link:
- 25, , ( 2004) Nascent membrane and secretory proteins differ in FRET-detected folding far inside the ribosome and in their exposure to ribosomal proteins. Cell 116: 725–736.
- 26
- 27, ( 2005) Hsp70 chaperones: cellular functions and molecular mechanism. Cell Mol Life Sci 62: 670–684.
- 28, , , , ( 2001) Prediction of amyloid fibril-forming proteins. J Biol Chem 276: 12945–12950.
- 29, ( 2004) Specialized membrane-localized chaperones prevent aggregation of polytopic proteins in the ER. J Cell Biol 168: 79–88.
- 30, , , , , ( 2003) A high-molecular-weight complex of membrane proteins BAP29/BAP31 is involved in the retention of membrane-bound IgD in the endoplasmic reticulum. Proc Natl Acad Sci USA 100: 9861–9866.
- 31, ( 2004) High-level expression of proteins in mammalian cells using transcription regulatory sequences from the Chinese hamster EF-1α gene. Biotechnol Prog 20: 880–889.Direct Link:
- 32( 2002) The SPOT-synthesis technique. Synthetic peptide arrays on membranes supports-principles and applications. J Immunol Methods 267: 13–26.

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