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The Brichos domain of prosurfactant protein C can hold and fold a transmembrane segment

  1. Hanna Johansson,
  2. Maria Eriksson,
  3. Kerstin Nordling,
  4. Jenny Presto,
  5. Jan Johansson*

Article first published online: 30 MAR 2009

DOI: 10.1002/pro.123

Issue

Protein Science

Protein Science

Volume 18, Issue 6, pages 1175–1182, June 2009

Additional Information

How to Cite

Johansson, H., Eriksson, M., Nordling, K., Presto, J. and Johansson, J. (2009), The Brichos domain of prosurfactant protein C can hold and fold a transmembrane segment. Protein Science, 18: 1175–1182. doi: 10.1002/pro.123

Author Information

  1. Department of Anatomy, Physiology and Biochemistry, SLU, The Biomedical Centre, 751 23 Uppsala, Sweden

*Department of Anatomy, Physiology and Biochemistry, SLU, The Biomedical Centre, 751 23 Uppsala, Sweden

Publication History

  1. Issue published online: 26 MAY 2009
  2. Article first published online: 30 MAR 2009
  3. Accepted manuscript online: 30 MAR 2009 12:00AM EST
  4. Manuscript Accepted: 23 MAR 2009
  5. Manuscript Revised: 16 MAR 2009
  6. Manuscript Received: 28 JAN 2009

Funded by

  • Swedish Research Council. Grant Number: 10371
  • Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning

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References

  • 1
    Brown NJ, Johansson J, Barron AE ( 2008) Biomimicry of surfactant protein C. Acc Chem Res 41: 1409–1417.
  • 2
    Whitsett JA, Weaver TE ( 2002) Hydrophobic surfactant proteins in lung function and disease. N Engl J Med 347: 2141–2148.
  • 3
    Beers MF, Mulugeta, S ( 2005) Surfactant protein C biosynthesis and its emerging role in conformational lung disease. Annu Rev Physiol 67: 663–696.
  • 4
    Almlén A, Stichtenoth G, Linderholm B, Haegerstrand-Björkman M, Robertson B, Johansson J, Curstedt T ( 2008) Surfactant proteins B and C are both necessary for alveolar stability at end expiration in premature rabbits with respiratory distress syndrome. J Appl Phys 104: 1101–1108.
  • 5
    Johansson J, Weaver TE, Tjernberg LO ( 2004) Proteolytic generation and aggregation of peptides from transmembrane regions: lung surfactant protein C and amyloid β-peptide. Cell Mol Life Sci 61: 326–335.
  • 6
    Gustafsson M, Thyberg J, Naslund J, Eliasson E, Johansson J ( 1999) Amyloid fibril formation by pulmonary surfactant protein C. FEBS Lett 464: 138–142.
  • 7
    Hamvas A, Cole FS, Nogee LM ( 2007) Genetic disorders of surfactant proteins. Neonatology 91: 311–317.
  • 8
    Nerelius C, Martin E, Peng S, Gustafsson M, Nordling K, Weaver TE, Johansson J ( 2008) Mutations linked to interstitial lung disease can abrogate anti-amyloid function of prosurfactant protein C. Biochem J 41: 201–209.
  • 9
    Westermark P ( 2005) Aspects on human amyloid forms and their fibril polypeptides. FEBS J 272: 5942–5949.
    Direct Link:
  • 10
    Ecroyd H, Carver JA ( 2009) Crystallin proteins and amyloid fibrils. Cell Mol Life Sci 66: 62–81.
  • 11
    Muchowski PJ ( 2002) Protein misfolding, amyloid formation, and neurodegeneration. A critical role for molecular chaperones? Neuron 35: 9–12.
  • 12
    Muchowski PJ, Wacker JL ( 2005) Modulation of neurodegeneration by molecular chaperones. Nat Rev 6: 11–22.
  • 13
    Shorter J, Lindquist S ( 2008) Hsp104, Hsp70 and Hsp40 interplay regulates formation, growth an elimination of Sup35 prions. EMBO J 27: 2712–2724.
  • 14
    Ecroyd H, Carver JA ( 2008) Unraveling the mysteries of protein folding and misfolding. IUBMB Life 60: 769–774.
    Direct Link:
  • 15
    Johansson H, Nordling K, Weaver TE, Johansson J ( 2006) The Brichos domain-containing C-terminal part of pro-surfactant protein C binds to an unfolded poly-val transmembrane segment. J Biol Chem 281: 21032–21039.
  • 16
    Sanchez-Pulido L, Devos D, Valencia A ( 2002) BRICHOS: a conserved domain in proteins associated with dementia, respiratory distress and cancer. Trends Biochem Sci 27: 329–332.
  • 17
    Westley BR, Griffin SM, May FE ( 2005) Interaction between TFF1, a gastric tumor suppressor trefoil protein, and TFIZ1, a brichos domain-containing protein with homology to SP-C. Biochemistry 44: 7967–7975.
  • 18
    Casals C, Johansson H, Saenz A, Gustafsson M, Alfonso C, Nordling K, Johansson J ( 2008) C-terminal, endoplasmic reticulum-lumenal domain of prosurfactant protein C - structural features and membrane interactions. FEBS J 275: 536–547.
    Direct Link:
  • 19
    Kota J, Gilstring F, Ljungdahl PO ( 2007) Membrane chaperone Shr3 assists in folding amino acid permeases preventing precocious ERAD. J Cell Biol 176: 616–628.
  • 20
    Dluhy RA, Shanmukh S, Leapard JB, Krüger P, Baatz JE ( 2003) Deacylated pulmonary surfactant protein SP-C transforms from α-helical to amyloid fibril structure via a pH-dependent mechanism: an infrared structural investigation. Biophys J 85: 2417–2429.
  • 21
    Gustafsson M, Griffiths WJ, Furusjö E, Johansson J ( 2001) The palmitoyl groups of lung surfactant protein C reduce unfolding into a fibrillogenic intermediate. J Mol Biol 310: 937–950.
  • 22
    Li J, Hosia W, Hamvas A, Thyberg J, Jornvall H, Weaver TE, Johansson J ( 2004) The N-terminal propeptide of lung surfactant protein C is necessary for biosynthesis and prevents unfolding of a metastable α-helix. J Mol Biol 338: 857–862.
  • 23
    Li J, Liepinsh E, Almlén A, Thyberg J, Curstedt T, Jörnvall H, Johansson J ( 2006) Structure and influence on stability and activity of the N-terminal propeptide part of lung surfactant protein C. FEBS J 273: 926–935.
    Direct Link:
  • 24
    Szyperski T, Vandenbussche G, Curstedt T, Ruysschaert JM, Wuthrich K, Johansson J ( 1998) Pulmonary surfactant-associated polypeptide C in a mixed organic solvent transforms from a monomeric α-helical state into insoluble β-sheet aggregates. Protein Sci 7: 2533–2540.
    Direct Link:
  • 25
    Woolhead CA, McCormick PJ, Johnson AE ( 2004) Nascent membrane and secretory proteins differ in FRET-detected folding far inside the ribosome and in their exposure to ribosomal proteins. Cell 116: 725–736.
  • 26
    Mingarro I, Nilsson I, Whitley P, von Heijne G ( 2000) Different conformations of nascent polypeptides during translocation across the ER membrane. BMC Cell Biol 1: 3.
  • 27
    Mayer MP, Bukau B ( 2005) Hsp70 chaperones: cellular functions and molecular mechanism. Cell Mol Life Sci 62: 670–684.
  • 28
    Kallberg Y, Gustafsson M, Persson B, Thyberg J, Johansson J ( 2001) Prediction of amyloid fibril-forming proteins. J Biol Chem 276: 12945–12950.
  • 29
    Kota J, Ljungdahl PO ( 2004) Specialized membrane-localized chaperones prevent aggregation of polytopic proteins in the ER. J Cell Biol 168: 79–88.
  • 30
    Schamel WWA, Kuppig S, Becker B, Gimborn K, Hauri HP, Reth M ( 2003) A high-molecular-weight complex of membrane proteins BAP29/BAP31 is involved in the retention of membrane-bound IgD in the endoplasmic reticulum. Proc Natl Acad Sci USA 100: 9861–9866.
  • 31
    Running Deer J, Allison DS ( 2004) High-level expression of proteins in mammalian cells using transcription regulatory sequences from the Chinese hamster EF-1α gene. Biotechnol Prog 20: 880–889.
    Direct Link:
  • 32
    Frank R ( 2002) The SPOT-synthesis technique. Synthetic peptide arrays on membranes supports-principles and applications. J Immunol Methods 267: 13–26.
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