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Insight into a strategy for attenuating AmpC-mediated β-lactam resistance: Structural basis for selective inhibition of the glycoside hydrolase NagZ

  1. Misty D. Balcewich1,
  2. Keith A. Stubbs2,†,
  3. Yuan He3,
  4. Terrence W. James1,
  5. Gideon J. Davies3,
  6. David J. Vocadlo2,
  7. Brian L. Mark1,*

Article first published online: 16 APR 2009

DOI: 10.1002/pro.137

Issue

Protein Science

Protein Science

Volume 18, Issue 7, pages 1541–1551, July 2009

Additional Information

How to Cite

Balcewich, M. D., Stubbs, K. A., He, Y., James, T. W., Davies, G. J., Vocadlo, D. J. and Mark, B. L. (2009), Insight into a strategy for attenuating AmpC-mediated β-lactam resistance: Structural basis for selective inhibition of the glycoside hydrolase NagZ. Protein Science, 18: 1541–1551. doi: 10.1002/pro.137

Author Information

  1. 1

    Department of Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada R3T 2N2

  2. 2

    Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada V5A 1S6

  3. 3

    York Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York YO10 5YW, United Kingdom

  1. †

    Chemistry M313, School of Biomedical, Biomolecular and Chemical Sciences, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009

*Department of Microbiology, University of Manitoba, 418 Buller Building, Winnipeg, Manitoba, Canada, R3T 2N2

Publication History

  1. Issue published online: 23 JUN 2009
  2. Article first published online: 16 APR 2009
  3. Accepted manuscript online: 16 APR 2009 12:00AM EST
  4. Manuscript Accepted: 30 MAR 2009
  5. Manuscript Revised: 27 MAR 2009
  6. Manuscript Received: 29 JAN 2009

Funded by

  • Natural Science and Engineering Council of Canada
  • Canadian Cystic Fibrosis Foundation
  • Canadian Institutes of health research
  • Biotechnology and Biological Sciences Research Council (BBSRC)

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