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Crystal structure of checkpoint kinase 2 in complex with NSC 109555, a potent and selective inhibitor

  1. George T. Lountos1,
  2. Joseph E. Tropea1,
  3. Di Zhang1,
  4. Andrew G. Jobson2,
  5. Yves Pommier2,
  6. Robert H. Shoemaker3,
  7. David S. Waugh1,*

Article first published online: 2 DEC 2008

DOI: 10.1002/pro.16

Issue

Protein Science

Protein Science

Volume 18, Issue 1, pages 92–100, January 2009

Additional Information

How to Cite

Lountos, G. T., Tropea, J. E., Zhang, D., Jobson, A. G., Pommier, Y., Shoemaker, R. H. and Waugh, D. S. (2009), Crystal structure of checkpoint kinase 2 in complex with NSC 109555, a potent and selective inhibitor. Protein Science, 18: 92–100. doi: 10.1002/pro.16

Author Information

  1. 1

    Macromolecular Crystallography Laboratory, National Cancer Institute at Frederick, P. O. Box B, Frederick, Maryland 21702-1201

  2. 2

    Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892

  3. 3

    Screening Technologies Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute at Frederick, P. O. Box B, Frederick, Maryland 21702-1201

*Macromolecular Crystallography Laboratory, National Cancer Institute at Frederick, P. O. Box B, Frederick, MD 21702-1201

Publication History

  1. Issue published online: 16 DEC 2008
  2. Article first published online: 2 DEC 2008
  3. Manuscript Accepted: 13 OCT 2008
  4. Manuscript Revised: 9 OCT 2008
  5. Manuscript Received: 25 AUG 2008

Funded by

  • NIH
  • National Cancer Institute
  • Center for Cancer Research

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