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Review
The bacterial outer membrane β-barrel assembly machinery
Article first published online: 1 MAY 2012
DOI: 10.1002/pro.2069
Copyright © 2012 The Protein Society
Additional Information
How to Cite
Kim, K. H., Aulakh, S. and Paetzel, M. (2012), The bacterial outer membrane β-barrel assembly machinery. Protein Science, 21: 751–768. doi: 10.1002/pro.2069
Publication History
- Issue published online: 17 MAY 2012
- Article first published online: 1 MAY 2012
- Accepted manuscript online: 30 MAR 2012 02:46PM EST
- Manuscript Accepted: 20 MAR 2012
- Manuscript Received: 26 JAN 2012
- Abstract
- Article
- References
- Cited By
Keywords:
- outer membrane proteins;
- β-barrel assembly machinery;
- outer membrane;
- protein folding;
- β-barrels
Abstract
β-Barrel proteins found in the outer membrane of Gram-negative bacteria serve a variety of cellular functions. Proper folding and assembly of these proteins are essential for the viability of bacteria and can also play an important role in virulence. The β-barrel assembly machinery (BAM) complex, which is responsible for the proper assembly of β-barrels into the outer membrane of Gram-negative bacteria, has been the focus of many recent studies. This review summarizes the significant progress that has been made toward understanding the structure and function of the bacterial BAM complex.