Sensing the messenger: The diverse ways that bacteria signal through c-di-GMP

Authors

  • Petya Violinova Krasteva,

    1. Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853
    Current affiliation:
    1. G5 Unit Structural Biology of Bacterial Secretion, Institut Pasteur, 75015 Paris, France
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  • Krista Michelle Giglio,

    1. Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853
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  • Holger Sondermann

    Corresponding author
    1. Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853
    • Department of Molecular Medicine, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853
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Abstract

An intracellular second messenger unique to bacteria, c-di-GMP, has gained appreciation as a key player in adaptation and virulence strategies, such as biofilm formation, persistence, and cytotoxicity. Diguanylate cyclases containing GGDEF domains and phosphodiesterases containing either EAL or HD-GYP domains have been identified as the enzymes controlling intracellular c-di-GMP levels, yet little is known regarding signal transmission and the sensory targets for this signaling molecule. Although limited in number, identified c-di-GMP receptors in bacteria are characterized by prominent diversity and multilevel impact. In addition, c-di-GMP has been shown to have immunomodulatory effects in mammals and several eukaryotic c-di-GMP sensors have been proposed. The structural biology of c-di-GMP receptors is a rapidly developing field of research, which holds promise for the development of novel therapeutics against bacterial infections. In this review, we highlight recent advances in identifying bacterial and eukaryotic c-di-GMP signaling mechanisms and emphasize the need for mechanistic structure–function studies on confirmed signaling targets.

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