1469-896X/asset/olbannerleft.gif?v=1&s=d218899ae53b2862ab119790ed504b8d72122fb3)
1469-896X/asset/olbannerright.gif?v=1&s=59470eb9a1d9b7b13b1be75e9445e6c46ee2214f)
Article
You have full text access to this OnlineOpen article
Single molecule effects of osteogenesis imperfecta mutations in tropocollagen protein domains
Article first published online: 2 DEC 2008
DOI: 10.1002/pro.21
Copyright © 2008 The Protein Society
Additional Information
How to Cite
Gautieri, A., Vesentini, S., Redaelli, A. and Buehler, M. J. (2009), Single molecule effects of osteogenesis imperfecta mutations in tropocollagen protein domains. Protein Science, 18: 161–168. doi: 10.1002/pro.21
Publication History
- Issue published online: 16 DEC 2008
- Article first published online: 2 DEC 2008
- Accepted manuscript online: 2 DEC 2008 12:00AM EST
- Manuscript Accepted: 6 OCT 2008
- Manuscript Revised: 5 OCT 2008
- Manuscript Received: 21 JUL 2008
Funded by
- Progetto-Rocca Fund
- MIT-Italy Program
- Solomon Buchsbaum AT&T Research Fund
- National Science Foundation CAREER Award. Grant Number: CMMI-0642545
- Army Research Office. Grant Number: W911NF-06-1-0291
References
- 1, , , , , , , , , ( 2001) Osteogenesis imperfecta at the beginning of bone and joint decade. Croat Med J 42: 393–415.
- 2, ( 2004) Osteogenesis imperfecta. Lancet 363: 1377–1385.
- 3, , ( 1979) Genetic heterogeneity in osteogenesis imperfecta. J Med Genet 16: 101–116.
- 4, , , , , , , ( 2004) Brittle IV mouse model for osteogenesis imperfecta IV demonstrates postpubertal adaptations to improve whole bone strength. J Bone Miner Res 19: 614–622.Direct Link:
- 5( 1997) The human type I collagen mutation database. Nucleic Acid Res 25: 181–187.
- 6
- 7, , ( 1997) Amino acid environment modulates the disruption by osteogenesis imperfecta glycine substitutions in collagen-like peptides. Biochemistry 36: 6930–6935.
- 8, , , , , ( 2000) Destabilization of osteogenesis imperfecta collagen-like model peptides correlates with the identity of the residue replacing glycine. Proc Natl Acad Sci USA 97: 4273–4278, doi:10.1016/j.jmbbm.2008. 03.001.
- 9( 2001) Folding defects in fibrillar collagens. Philos Trans Royal Soc Lond B Biol Sci 356: 151–157.
- 10, , (in press). Deformation rate controls elasticity and unfolding pathway of single tropocollagen molecules. J Mech Behav Biomed Mater. doi:10.1016/j.jmbbm.2008.03.001.
- 11( 2006) Nature designs tough collagen: explaining the nanostructure of collagen fibrils. Proc Natl Acad Sci USA 103: 12285–12290.
- 12, , , , , ( 2006) Cooperative deformation of mineral and collagen in bone at the nanoscale. Proc Natl Acad Sci USA 103: 17741–17746.
- 13( 2008) Molecular architecture of collagen fibrils: a critical length scale for tough fibrils. Curr Appl Phys 8: 440–442.
- 14, ( 1996) Stress–strain curve and Young's modulus of a collagen molecule as determined by the X-ray diffraction technique. J Biomech 29: 655–658.
- 15, , , ( 2004) Stretching type II collagen with optical tweezers. J Biomech 37: 1665–1669.
- 16, ( 1982) Theory of dislocations. Wiley-Interscience, New York.
- 17( 1999) Cracks and fracture. Academic Press, San Diego.
- 18( 2001) Crystal, defects and microstructure—modeling across scales. Cambridge University Press, Cambridge.
- 19, ( 1982) A simple method for displaying the hydropathic character of a protein. J Mol Biol 157: 105–132.
- 20, , , , ( 2000) Hydration dynamics of the collagen triple helix. J Mol Biol 300: 1041–1048.
- 21, , ( 2008) Muscle dystrophy single point mutation in the 2B segment of lamin A does not affect the mechanical properties at the dimer level. J Biomech 41: 1295–1301.
- 22, , ( 2007) Folding and misfolding of the collagen triple helix: Markov analysis of molecular dynamics simulations. Biophys J 93: 4108–4115.
- 23, ( 2007) Entropic elasticity controls nanomechanics of single tropocollagen molecules. Biophys J 93: 37–43.
- 24( 2008) Nanomechanics of collagen fibrils under varying cross-link densities: atomistic and continuum studies. J Mech Behav Biomed Mater 1: 59–67.
- 25, ( 2004) A statistically derived parameterization for the collagen triple-helix. Protein Sci 13: 2276.Direct Link:
- 26, ( 2004) An interactive triple-helical collagen builder. Bioinformatics 20: 2458–2459.
- 27, , , ( 1994) Crystal-structure and molecular-structure of a collagen-like peptide at 1.9-angstrom resolution. Science 266: 75–81.
- 28, ( 2005) Elastic properties, Young's modulus determination and structural stability of the tropocollagen molecule: a computational study by steered molecular dynamics. J Biomech 38: 1527–1533.
- 29, , , ( 2005) Molecular assessment of the elastic properties of collagen-like homotrimer sequences. Biomech Model Mechanobiol 3: 224–234.
- 30( 2006) Atomistic and continuum modeling of mechanical properties of collagen: elasticity, fracture and self-assembly. J Mater Res 21: 1947–1961.
- 31, , ( 1995) Gromacs—a message-passing parallel molecular-dynamics implementation. Comput Phys Commun 91: 43–56.
- 32, , ( 1995) Gromacs—a software package and a parallel computer for molecular-dynamics. Abstr Pap Am Chem Soc 209: 49.