SEARCH

SEARCH BY CITATION

References

  • 1
    Hay AJ, Wolstenholme AJ, Skehel JJ, Smith MH ( 1985) The molecular basis of the specific anti-influenza action of amantadine. EMBO J 4: 30213024.
  • 2
    Park EK, Castrucci MR, Portner A, Kawaoka Y ( 1998) The M2 ectodomain is important for its incorporation into influenza A virions. J Virol 72: 24492455.
  • 3
    Pinto LH, Dieckmann GR, Gandhi CS, Papworth CG, Braman J, Shaughnessy MA, Lear JD, Lamb RA, DeGrado WF ( 1997) A functionally defined model for the M2 proton channel of influenza A virus suggests a mechanism for its ion selectivity. Proc Natl Acad Sci USA 94: 1130111306.
  • 4
    Gandhi CS, Shuck K, Lear JD, Dieckmann GR, DeGrado WF, Lamb RA, Pinto LH ( 1999) Cu(II) inhibition of the proton translocation machinery of the influenza A virus M2 protein. J Biol Chem 274: 54745482.
  • 5
    Cady SD, Schmidt-Rohr K, Wang J, Soto CS, DeGrado WF, Hong M ( 2010) Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers. Nature 463: 689692.
  • 6
    Pinto LH, Holsinger LJ, Lamb RA ( 1992) Influenza virus M2 protein has ion channel activity. Cell 69: 517528.
  • 7
    Pinto LH, Lamb RA ( 2006) The M2 proton channels of influenza A and B viruses. J Biol Chem 281: 89979000.
  • 8
    Rossman JS, Jing X, Leser GP, Lamb RA ( 2010) Influenza virus M2 protein mediates ESCRT-independent membrane scission. Cell 142: 902913.
  • 9
    McCown MF, Pekosz A ( 2006) Distinct domains of the influenza a virus M2 protein cytoplasmic tail mediate binding to the M1 protein and facilitate infectious virus production. J Virol 80: 81788189.
  • 10
    Ciampor F, Cmarko D, Cmarková J, Závodská E ( 1995) Influenza virus M2 protein and haemagglutinin conformation changes during intracellular transport. Acta Virol 39: 171181.
  • 11
    Bright RA, Medina MJ, Xu X, Perez-Oronoz G, Wallis TR, Davis XM, Povinelli L, Cox NJ, Klimov AI ( 2005) Incidence of adamantane resistance among influenza A (H3N2) viruses isolated worldwide from 1994 to 2005: a cause for concern. Lancet 366: 11751181.
  • 12
    Wang C, Lamb RA, Pinto LH ( 1995) Activation of the M2 ion channel of influenza virus: a role for the transmembrane domain histidine residue. Biophys J 69: 13631371.
  • 13
    Tang Y, Zaitseva F, Lamb RA, Pinto LH ( 2002) The gate of the influenza virus M2 proton channel is formed by a single tryptophan residue. J Biol Chem 277: 3988039886.
  • 14
    Kochendoerfer GG, Salom D, Lear JD, Wilk-Orescan R, Kent SB, DeGrado WF ( 1999) Total chemical synthesis of the integral membrane protein influenza A virus M2: role of its C-terminal domain in tetramer assembly. Biochemistry 38: 1190511913.
  • 15
    Salom D, Hill BR, Lear JD, DeGrado WF ( 2000) pH-dependent tetramerization and amantadine binding of the transmembrane helix of M2 from the influenza A virus. Biochemistry 39: 1416014170.
  • 16
    Ma C, Polishchuk AL, Ohigashi Y, Stouffer AL, Schön A, Magavern E, Jing X, Lear JD, Freire E, Lamb RA, DeGrado WF, Pinto LH ( 2009) Identification of the functional core of the influenza A virus A/M2 proton-selective ion channel. Proc Natl Acad Sci USA 106: 1228312288.
  • 17
    Schnell JR, Chou JJ ( 2008) Structure and mechanism of the M2 proton channel of influenza A virus. Nature 451: 591595.
  • 18
    Stouffer AL, Acharya R, Salom D, Levine AS, Di Costanzo L, Soto CS, Tereshko V, Nanda V, Stayrook S, DeGrado WF ( 2008) Structural basis for the function and inhibition of an influenza virus proton channel. Nature 451: 596599.
  • 19
    Sharma M, Yi M, Dong H, Qin H, Peterson E, Busath D, Zhou HX, Cross TA ( 2010) Atomistic mechanism of the influenza A proton channel from a structure solved in a lipid bilayer. Science 330: 509512.
  • 20
    Sansom MSP, Kerr ID, Smith GR, Son HS ( 1997) The influenza A virus M2 channel: a molecular modeling and simulation study. Virology 233: 163173.
  • 21
    Balannik V, Carnevale V, Fiorin G, Levine BG, Lamb RA, Klein ML, Degrado WF, Pinto LH ( 2010) Functional studies and modeling of pore-lining residue mutants of the influenza a virus M2 ion channel. Biochemistry 49: 696708.
  • 22
    Jing X, Ma C, Ohigashi Y, Oliveira FA, Jardetzky TS, Pinto LH, Lamb RA ( 2008) Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel. Proc Natl Acad Sci USA 105: 1096710972.
  • 23
    Ohigashi Y, Ma C, Jing X, Balannick V, Pinto LH, Lamb RA ( 2009) An amantadine-sensitive chimeric BM2 ion channel of influenza B virus has implications for the mechanism of drug inhibition. Proc Natl Acad Sci USA 106: 1877518779.
  • 24
    Rosenberg MR, Casarotto MG ( 2010) Coexistence of two adamantane binding sites in the influenza A M2 ion channel. Proc Natl Acad Sci USA 107: 1386613871.
  • 25
    Khurana E, Devane RH, Dal Peraro M, Klein ML ( 2011) Computational study of drug binding to the membrane-bound tetrameric M2 peptide bundle from influenza A virus. Biochim Biophys Acta 2010: 530537.
  • 26
    Cady SD, Mishanina TV, Hong M ( 2009) Structure of amantadine-bound M2 transmembrane peptide of influenza A in lipid bilayers from magic-angle-spinning solid-state NMR: the role of Ser31 in amantadine binding. J Mol Biol 385: 11271141.
  • 27
    Cady SD, Wang J, Wu Y, DeGrado WF, Hong M ( 2011) Specific binding of adamantane drugs and direction of their polar amines in the pore of the influenza M2 transmembrane domain in lipid bilayers and dodecylphosphocholine micelles determined by NMR spectroscopy. J Am Chem Soc 133: 42744284.
  • 28
    Hu J, Fu R, Nishimura K, Zhang L, Zhou HX, Busath DD, Vijayvergiya V, Cross TA ( 2006) Histidines, heart of the hydrogen ion channel from influenza A virus: toward an understanding of conductance and proton selectivity. Proc Natl Acad Sci USA 103: 68656870.
  • 29
    Hu F, Schmidt-Rohr K, Hong M ( 2012) NMR detection of pH-dependent histidine-water proton exchange reveals the conduction mechanism of a transmembrane proton channel. J Am Chem Soc 134: 37033713.
  • 30
    Hu F, Luo W, Hong M ( 2010) Mechanisms of proton conduction and gating by influenza M2 proton channels from solid-state NMR. Science 330: 505508.
  • 31
    Acharya A, Carnevale V, Fiorin G, Levine BG, Polishchuk A, Balannick V, Samish I, Lamb RA, Pinto LH, DeGrado WF, Klein ML ( 2010) Structural mechanism of proton transport through the influenza A M2 protein. Proc Natl Acad Sci USA 107: 1507515080.
  • 32
    Shimbo K, Brassard DL, Lamb RA, Pinto LH ( 1996) Ion selectivity and activation of the M2 ion channel of influenza virus. Biophys J 70: 13351346.
  • 33
    Mould JA, Drury JE, Frings SM, Kaupp UB, Pekosz A, Lamb RA, Pinto LH ( 2000) Permeation and activation of the M2 ion channel of influenza A virus. J Biol Chem 275: 3103831050.
  • 34
    Mould JA, Li HC, Dudlak CS, Lear JD, Pekosz A, Lamb RA, Pinto LH ( 2000) Mechanism for proton conduction of the M(2) ion channel of influenza A virus. J Biol Chem 275: 85928599.
  • 35
    Mustafa M, Henderson DJ, Busath DD ( 2009) Free-energy profiles for ions in the influenza M2-TMD channel. Proteins 76: 794807.
  • 36
    Leiding T, Wang J, Martinsson J, DeGrado WF, Arsköld SP ( 2010) Proton and cation transport activity of the M2 proton channel from influenza A virus. Proc Natl Acad Sci USA 107: 1540915414.
  • 37
    Decoursey TE ( 2003) Voltage-gated proton channels and other proton transfer pathways. Physiol Rev 83: 475579.
  • 38
    Pielak RM, Chou JJ ( 2010) Kinetic analysis of the M2 proton conduction of the influenza virus. J Am Chem Soc 132: 1769517697.
  • 39
    Chizhmakov IV, Geraghty FM, Ogden DC, Hayhurst A, Antoniou M, Hay AJ ( 1996) Selective proton permeability and pH regulation of the influenza virus M2 channel expressed in mouse erythroleukaemia cells. J Physiol 494: 329336.
  • 40
    Markley JL ( 1975) Observation of histidine residues in proteins by means of nuclear magnetic resonance spectroscopy. Acc Chem Res 8: 7080.
  • 41
    Forrest LR, DeGrado WF, Dieckmann GR, Sansom MS ( 1998) Two models of the influenza A M2 channel domain: verification by comparison. Fold Des 3: 443448.
  • 42
    Grambas S, Bennett MS, Hay AJ ( 1992) Influence of amantadine resistance mutations on the pH regulatory function of the M2 protein of influenza A viruses. Virology 191: 541549.
  • 43
    Shiraishi K, Mitamura K, Sakai-Tagawa Y, Goto H, Sugaya N, Kawaoka Y ( 2003) High frequency of resistant viruses harboring different mutations in amantadine-treated children with influenza. J Infect Dis 188: 5761.
  • 44
    Abed Y, Goyette N, Boivin G ( 2005) Generation and characterization of recombinant influenza A (H1N1) viruses harboring amantadine resistance mutations. Antimicrob Agents Chemother 49: 556559.
  • 45
    Suzuki H, Saito R, Masuda H, Oshitani H, Sato M, Sato I ( 2003) Emergence of amantadine-resistant influenza A viruses: epidemiological study. J Infect Chemother 9: 195200.
  • 46
    Deyde V, Garten R, Sheu T, Smith C, Myrick A, Barnes J, Xu X, Shaw M, Klimov A, Gubareva L ( 2009) Genomic events underlying the changes in adamantane resistance among influenza A(H3N2) viruses during 2006-2008. Influenza Other Respi Viruses 3: 297314.
  • 47
    Deyde VM, Xu X, Bright RA, Shaw M, Smith CB, Zhang Y, Shu Y, Gubareva LV, Cox NJ, Klimov AI ( 2007) Surveillance of resistance to adamantanes among influenza A(H3N2) and A(H1N1) viruses isolated worldwide. J Infect Dis 196: 249257.
  • 48
    Krumbholz A, Schmidtke M, Bergmann S, Motzke S, Bauer K, Stech J, Durrwald R, Wutzler P, Zell R ( 2009) High prevalence of amantadine resistance among circulating European porcine influenza A viruses. J Gen Virol 90: 900908.
  • 49
    Simonsen L, Viboud C, Grenfell BT, Dushoff J, Jennings L, Smit M, Macken C, Hata M, Gog J, Miller MA, Holmes EC ( 2007) The genesis and spread of reassortment human influenza A/H3N2 viruses conferring adamantane resistance. Mol Biol Evol 24: 18111820.
  • 50
    Bright RA, Shay DK, Shu B, Cox NJ, Klimov AI ( 2006) Adamantane resistance among influenza A viruses isolated early during the 2005-2006 influenza season in the United States. JAMA 295: 891894.
  • 51
    Salter A, Ni Laoi B, Crowley B ( 2011) Emergence and phylogenetic analysis of amantadine-resistant influenza a subtype H3N2 viruses in Dublin, Ireland, over six seasons from 2003/2004 to 2008/2009. Intervirology 54: 305315.
  • 52
    Tosh C, Murugkar HV, Nagarajan S, Tripathi S, Katare M, Jain R, Khandia R, Syed Z, Behera P, Patil S, Kulkarni DD, Dubey SC ( 2011) Emergence of amantadine-resistant avian influenza H5N1 virus in India. Virus Genes 42: 1015.
  • 53
    Ujike M, Ejima M, Anraku A, Shimabukuro K, Obuchi M, Kishida N, Hong X, Takashita E, Fujisaki S, Yamashita K, Horikawa H, Kato Y, Oguchi A, Fujita N, Tashiro M, Odagiri T ( 2011) Monitoring and characterization of oseltamivir-resistant pandemic (H1N1) 2009 virus, Japan, 2009-2010. Emerg Infect Dis 17: 470479.
  • 54
    Zaraket H, Saito R, Suzuki Y, Baranovich T, Dapat C, Caperig-Dapat I, Suzuki H ( 2010) Genetic makeup of amantadine-resistant and oseltamivir-resistant human influenza A/H1N1 viruses. J Clin Microbiol 48: 10851092.
  • 55
    Kiselev OI, Komissarov AB, Stukova MA, Buzitskaia Zh V, Pisareva MM, Elpaeva EA, Danilenko DM, Konovalova NI, Gudkova TM, Grigor'eva VA, Smirnova TS, Slita AV, Romanovskaia-Roman'ko EA, Tsybalova LM, Sominina AA, Eropkin M, Grudinin MP ( 2011) [The 2009 pandemic influenza in Russia. I. Diagnosis and molecular biological characteristics of the virus]. Vopr Virusol 56: 1721.
  • 56
    Puzelli S, Facchini M, Di Martino A, Fabiani C, Lackenby A, Zambon M, Donatelli I ( 2011) Evaluation of the antiviral drug susceptibility of influenza viruses in Italy from 2004/05 to 2009/10 epidemics and from the recent 2009 pandemic. Antiviral Res 90: 205212.
  • 57
    Zhou J, Zou L, Zhang X, Liao J, Ni H, Hou N, Wang Y, Li H, Wu J, Jonges M, Meijer A, Koopmans M, Ke C ( 2011) Adamantane- and oseltamivir-resistant seasonal A (H1N1) and pandemic A (H1N1) 2009 influenza viruses in Guangdong, China, during 2008 and 2009. J Clin Microbiol 49: 26512655.
  • 58
    Dapat C, Suzuki Y, Kon M, Tamura T, Saito R, Dapat IC, Yamazaki O, Odagiri T, Fujisaki S, Suzuki H ( 2011) Phylogenetic analysis of an off-seasonal influenza virus A (H3N2) in Niigata, Japan, 2010. Japan J Infect Dis 64: 237241.
  • 59
    Qu Y, Zhang R, Cui P, Song G, Duan Z, Lei F ( 2011) Evolutionary genomics of the pandemic 2009 H1N1 influenza viruses (pH1N 1v). Virol J 8: 250.
  • 60
    Gubareva LV, Trujillo AA, Okomo-Adhiambo M, Mishin VP, Deyde VM, Sleeman K, Nguyen HT, Sheu TG, Garten RJ, Shaw MW, Fry AM, Klimov AI ( 2010) Comprehensive assessment of 2009 pandemic influenza A (H1N1) virus drug susceptibility in vitro. Antivir Ther 15: 11511159.
  • 61
    Furuse Y, Suzuki A, Kamigaki T, Shimizu M, Fuji N, Oshitani H ( 2009) Reversion of influenza A (H3N2) virus from amantadine resistant to amantadine sensitive by further reassortment in Japan during the 2006-to-2007 influenza season. J Clin Microbiol 47: 841844.
  • 62
    Schmidtke M, Zell R, Bauer K, Krumbholz A, Schrader C, Suess J, Wutzler P ( 2006) Amantadine resistance among porcine H1N1, H1N2, and H3N2 influenza A viruses isolated in Germany between 1981 and 2001. Intervirology 49: 286293.
  • 63
    Stouffer AL, Ma C, Cristian L, Ohigashi Y, Lamb RA, Lear JD, Pinto LH, DeGrado WF ( 2008) The interplay of functional tuning, drug resistance, and thermodynamic stability in the evolution of the M2 proton channel from the influenza A virus. Structure: 10671076.
  • 64
    Howard KP, Lear JD, DeGrado WF ( 2002) Sequence determinants of the energetics of folding of a transmembrane four-helix-bundle protein. Proc Natl Acad Sci USA 99: 85688572.
  • 65
    Venkataraman P, Lamb RA, Pinto LH ( 2005) Chemical rescue of histidine selectivity filter mutants of the M2 ion channel of influenza A virus. J Biol Chem 280: 2146321472.
  • 66
    Okada A, Miura T, Takeuchi H ( 2001) Protonation of histidine and histidine-tryptophan interaction in the activation of the M2 ion channel from influenza A virus. Biochemistry 40: 60536060.
  • 67
    Takeuchi H, Okada A, Miura T ( 2003) Roles of the histidine and tryptophan side chains in the M2 proton channel from influenza A virus. FEBS Lett 552: 3538.
  • 68
    Betakova T, Ciampor F, Hay AJ ( 2005) Influence of residue 44 on the activity of the M2 proton channel of influenza A virus. J Gen Virol 86: 181184.
  • 69
    Chizhmakov IV, Ogden DC, Geraghty FM, Hayhurst A, Skinner A, Betakova T, Hay AJ ( 2003) Differences in conductance of M2 proton channels of two influenza viruses at low and high pH. J Physiol 546: 427438.
  • 70
    Cady SD, Luo WB, Hu F, Hong M ( 2009) Structure and function of the influenza M2 proton channel. Biochemistry 48: 73567364.
  • 71
    Cross TA, Sharma M, Yi M, Zhou HX ( 2010) Influence of solubilizing environments on membrane protein structures. Trends Biochem Sci [Epub ahead of print].
  • 72
    Pielak RM, Oxenoid K, Chou JJ ( 2011) Structural investigation of rimantadine inhibition of the AM2-BM2 chimera channel of influenza viruses. Structure 19: 16551663.
  • 73
    Wang J, Kim S, Kovacs F, Cross TA ( 2001) Structure of the transmembrane region of the M2 protein H+ channel. Protein Sci 10: 22412250.
  • 74
    Hu J, Asbury T, Achuthan S, Li C, Bertram R, Quine JR, Fu R, Cross TA ( 2007) Backbone structure of the amantadine-blocked trans-membrane domain M2 proton channel from Influenza A virus. Biophys J 92: 43354343.
  • 75
    Hong M ( 2006) Oligomeric structure, dynamics, and orientation of membrane proteins from solid-state NMR. Structure 14: 17311740.
  • 76
    Opella SJ, Marassi FM ( 2004) Structure determination of membrane proteins by NMR spectroscopy. Chem Rev 104: 35873606.
  • 77
    Tjandra N, Bax A ( 1997) Direct measurement of distances and angles in biomolecules by NMR in a dilute liquid crystalline medium. Science 278: 11111114.
  • 78
    Hong M ( 2006) Solid-state NMR studies of the structure, dynamics, and assembly of beta-sheet membrane peptides and alpha-helical membrane proteins with antibiotic activities. Acc Chem Res 39: 176183.
  • 79
    Hong M, Zhang Y, Hu F ( 2012) Membrane protein structure and dynamics from NMR spectroscopy. Annu Rev Phys Chem 63: 124.
  • 80
    Luca S, Heise H, Baldus M ( 2003) High-resolution solid-state NMR applied to polypeptides and membrane proteins. Acc Chem Res 36: 858865.
  • 81
    McDermott AE ( 2009) Structure and dynamics of membrane proteins by magic angle spinning solid-state NMR. Annu Rev Biophys 38: 385403.
  • 82
    Tycko R ( 2011) Solid-state NMR studies of amyloid fibril structure. Annu Rev Phys Chem 62: 279299.
  • 83
    Hong M, Mishanina TV, Cady SD ( 2009) Accurate measurement of methyl 13C chemical shifts by solid-state NMR for the determination of protein sidechain conformation: the influenza M2 transmembrane peptide as an example. J Am Chem Soc 131: 78067816.
  • 84
    Luo W, Mani R, Hong M ( 2007) Sidechain conformation and gating of the M2 transmembrane peptide proton channel of influenza A virus from solid-state NMR. J Phys Chem 111: 1082510832.
  • 85
    Cady SD, Hong M ( 2008) Amantadine-induced conformational and dynamical changes of the influenza M2 transmembrane proton channel. Proc Natl Acad Sci USA 105: 14831488.
  • 86
    Tian C, Gao PF, Pinto LH, Lamb RA, Cross TA ( 2003) Initial structural and dynamic characterization of the M2 protein transmembrane and amphipathic helices in lipid bilayers. Prot Sci 12: 25972605.
  • 87
    Luo W, Hong M ( 2010) Conformational changes of an ion channel membrane protein detected through water-protein interactions using solid-state NMR spectroscopy. J Am Chem Soc 132: 23782384.
  • 88
    Ghosh A, Qiu J, DeGrado WF, Hochstrasser RM ( 2011) Tidal surge in the M2 proton channel, sensed by 2D IR spectroscopy. Proc Natl Acad Sci USA 108: 61156120.
  • 89
    Khurana E, Dal Peraro M, DeVane R, Vemparala S, DeGrado WF, Klein ML ( 2009) Molecular dynamics calculations suggest a conduction mechanism for the M2 proton channel from influenza A virus. Proc Natl Acad Sci USA 106: 10691074.
  • 90
    Carnevale V, Fiorin G, Levine BG, Degrado WF, Klein ML ( 2010) Multiple proton confinement in the M2 channel from the influenza A virus. J Phys Chem C Nanomater Interfaces 114: 2085620863.
  • 91
    Su Y, Hu F, Hong M ( 2012) Paramagnetic Cu(II) for probing membrane protein structure and function: inhibition mechanism of the influenza M2 proton channel. J Am Chem Soc 134: 86938702.
  • 92
    Hong M, Fritzsching KJ, Williams J ( 2012) Hydrogen-bonding partner of the proton-conducting histidine in the influenza M2 proton channel revealed from 1H chemical shifts. J Am Chem Soc [Epub ahead of print].
  • 93
    Fischbach I, Spiess HW, Saalwachter K, Goward GR ( 2004) Solid state NMR spectroscopic investigations of model compounds for imidazole-based proton conductors. J Phys Chem 108: 1850018508.
  • 94
    Goward GR, Saalwächter K, Fischbach I, Spiess HW ( 2003) Reorientation phenomena in imidazolium methyl sulfonate as probed by advanced solid-state NMR. Solid State Nucl Magn Reson 24: 150162.
  • 95
    Lin TI, Schroeder C ( 2001) Definitive assignment of proton selectivity and attoampere unitary current to the M2 ion channel protein of influenza A virus. J Virol 75: 36473656.
  • 96
    Edgcomb SP, Murphy KP ( 2002) Variability in the pKa of histidine side-chains correlates with burial within proteins. Proteins 49: 16.
  • 97
    Hu F, Luo W, Cady SD, Hong M ( 2011) Conformational plasticity of the influenza A M2 transmembrane peptide in lipid bilayers under varying pH, drug binding and membrane thickness. Biochim Biophys Acta 1808: 415423.
  • 98
    Li C, Qin H, Gao FP, Cross TA ( 2007) Solid-state NMR characterization of conformational plasticity within the transmembrane domain of the influenza A M2 proton channel. Biochim Biophys Acta 1768: 31623170.
  • 99
    Wang C, Takeuchi K, Pinto LH, Lamb RA ( 1993) Ion channel activity of influenza A virus M2 protein: characterization of the amantadine block. J Virol 67: 55855594.
  • 100
    Cady SD, Wang T, Hong M ( 2011) Membrane-dependent effects of a cytoplasmic helix on the structure and drug binding of the influenza virus M2 protein. J Am Chem Soc 133: 1157211579.
  • 101
    Wang T, Cady SD, Hong M ( 2012) NMR determination of protein partitioning into membrane domains with different curvatures and application to the influenza M2 peptide. Biophys J 102: 787794.
  • 102
    Chuang GY, Kozakov D, Brenke R, Beglov D, Guarnieri F, Vajda S ( 2009) Binding hot spots and amantadine orientation in the influenza a virus M2 proton channel. Biophys J 97: 28462853.
  • 103
    Laohpongspaisan C, Rungrotmongkol T, Intharathep P, Malaisree M, Decha P, Aruksakunwong O, Sompornpisut P, Hannongbua S ( 2009) Why amantadine loses its function in influenza m2 mutants: MD simulations. J Chem Inf Model 49: 847852.
  • 104
    Kozakov D, Chuang GY, Beglov D, Vajda S ( 2010) Where does amantadine bind to the influenza virus M2 proton channel? Trends Biochem Sci 35: 471475.
  • 105
    Phongphanphanee S, Rungrotmongkol T, Yoshida N, Hannongbua S, Hirata F ( 2010) Proton transport through the influenza A M2 channel: three-dimensional reference interaction site model study. J Am Chem Soc 132: 97829788.
  • 106
    Astrahan P, Flitman-Tene R, Bennett ER, Krugliak M, Gilon C, Arkin IT ( 2010) Quantitative analysis of influenza M2 channel blockers. Biochim Biophys Acta. PMID: 20831860 {Medline}.
  • 107
    Wang J, Ma C, Fiorin G, Carnevale V, Wang T, Hu F, Lamb RA, Pinto LH, Hong M, Klein ML, DeGrado WF ( 2011) Molecular dynamics simulation directed rational design of inhibitors targeting drug-resistant mutants of influenza A virus M2. J Am Chem Soc 133: 1283412841.
  • 108
    Wang J, Qiu JX, Soto CS, DeGrado WF ( 2011) Structural and dynamic mechanisms for the function and inhibition of the M2 proton channel from influenza A virus. Curr Opin Struct Biol 21: 6880.
  • 109
    Gu RX, Liu LA, Wei DQ, Du JG, Liu L, Liu H ( 2011) Free energy calculations on the two drug binding sites in the M2 proton channel. J Am Chem Soc 133: 1081710825.
  • 110
    Rungrotmongkol T, Yotmanee P, Nunthaboot N, Hannongbua S ( 2011) Computational studies of influenza A virus at three important targets: hemagglutinin, neuraminidase and M2 protein. Curr Pharm Des 17: 17201739.
  • 111
    Wang J, Cady SD, Balannik V, Pinto LH, DeGrado WF, Hong M ( 2009) Discovery of spiro-piperidine inhibitors and their modulation of the dynamics of the M2 proton channel from influenza A virus. J Am Chem Soc 131: 80668076.
  • 112
    Tu Q, Pinto LH, Luo G, Shaughnessy MA, Mullaney D, Kurtz S, Krystal M, Lamb RA ( 1996) Characterization of inhibition of M2 ion channel activity by BL-1743, an inhibitor of influenza A virus. J Virol 70: 42464252.