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Crystal structures of a therapeutic single chain antibody in complex with two drugs of abuse—Methamphetamine and 3,4-methylenedioxymethamphetamine†

  1. Reha Celikel1,‡,
  2. Eric C. Peterson2,‡,
  3. S. Michael Owens2,
  4. Kottayil I. Varughese1,*

Article first published online: 16 SEP 2009

DOI: 10.1002/pro.244

Issue

Protein Science

Protein Science

Volume 18, Issue 11, pages 2336–2345, November 2009

Additional Information

How to Cite

Celikel, R., Peterson, E. C., Owens, S. M. and Varughese, K. I. (2009), Crystal structures of a therapeutic single chain antibody in complex with two drugs of abuse—Methamphetamine and 3,4-methylenedioxymethamphetamine. Protein Science, 18: 2336–2345. doi: 10.1002/pro.244

Author Information

  1. 1

    Department of Physiology and Biophysics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205

  2. 2

    Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205

  1. ‡

    Reha Celikel and Eric C. Peterson contributed equally to this work.

*Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, #750, 4301 W. Markham Street, Little Rock, AR 72205-7199

  1. †

    Financial Disclosure: S.M.O. has financial interest in and serves as Chief Scientific Officer for InterveXion Therapeutics LLC (Little Rock, AR), a pharmaceutical biotechnology company focused on treating drug addiction with antibody-based therapy.

Publication History

  1. Issue published online: 23 OCT 2009
  2. Article first published online: 16 SEP 2009
  3. Accepted manuscript online: 16 SEP 2009 12:00AM EST
  4. Manuscript Accepted: 4 SEP 2009
  5. Manuscript Revised: 1 SEP 2009
  6. Manuscript Received: 27 JUL 2009

Funded by

  • NIH. Grant Numbers: HL55375, DA11560, DA018039
  • Arkansas Biosciences Institute

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