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High tolerance to simultaneous active-site mutations in TEM-1 β-lactamase: Distinct mutational paths provide more generalized β-lactam recognition

  1. Pierre-Yves De Wals1,†,
  2. Nicolas Doucet1,‡,
  3. Joelle N. Pelletier1,2,*

Article first published online: 2 DEC 2008

DOI: 10.1002/pro.25

Issue

Protein Science

Protein Science

Volume 18, Issue 1, pages 147–160, January 2009

Additional Information

How to Cite

De Wals, P.-Y., Doucet, N. and Pelletier, J. N. (2009), High tolerance to simultaneous active-site mutations in TEM-1 β-lactamase: Distinct mutational paths provide more generalized β-lactam recognition. Protein Science, 18: 147–160. doi: 10.1002/pro.25

Author Information

  1. 1

    Département de Biochimie, Université de Montréal, Montréal Québec, Canada H3C 3J7

  2. 2

    Département de Chimie, Université de Montréal, Montréal Québec, Canada H3C 3J7

  1. †

    Verdezyne, Inc., 26061 Merit Circle #101, Laguna Hills, CA 92653-7010, USA

  2. ‡

    Department of Chemistry, Yale University, 225 Prospect Street, P.O. Box 208107, New Haven, CT 06520-8107, USA

*Département de Chimie, Université de Montréal, C. P. 6128, Succursale Centre-Ville, Montréal, Québec, Canada H3C 3J7

Publication History

  1. Issue published online: 16 DEC 2008
  2. Article first published online: 2 DEC 2008
  3. Accepted manuscript online: 2 DEC 2008 12:00AM EST
  4. Manuscript Accepted: 7 OCT 2008
  5. Manuscript Revised: 21 AUG 2008
  6. Manuscript Received: 11 JUN 2008

Funded by

  • Natural Sciences and Engineering Research Council of Canada (NSERC)
  • The Canada Foundation for Innovation (CFI)

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