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pH-dependent stability of neuroserpin is mediated by histidines 119 and 138; Implications for the control of β-sheet A and polymerization

  1. Didier Belorgey1,*,
  2. Peter Hägglöf1,
  3. Maki Onda2,
  4. David A. Lomas1

Article first published online: 1 DEC 2009

DOI: 10.1002/pro.299

Issue

Protein Science

Protein Science

Volume 19, Issue 2, pages 220–228, February 2010

Additional Information

How to Cite

Belorgey, D., Hägglöf, P., Onda, M. and Lomas, D. A. (2010), pH-dependent stability of neuroserpin is mediated by histidines 119 and 138; Implications for the control of β-sheet A and polymerization. Protein Science, 19: 220–228. doi: 10.1002/pro.299

Author Information

  1. 1

    Department of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Cambridge CB2 0XY, United Kingdom

  2. 2

    Department of Biological Science, Osaka Prefecture University, Nakaku, Sakai, Osaka 599-8570, Japan

*Department of Medicine, University of Cambridge, Cambridge Institute For Medical Research, Cambridge CB2 0XY, UK

Publication History

  1. Issue published online: 21 JAN 2010
  2. Article first published online: 1 DEC 2009
  3. Accepted manuscript online: 1 DEC 2009 12:00AM EST
  4. Manuscript Accepted: 16 NOV 2009
  5. Manuscript Revised: 24 SEP 2009
  6. Manuscript Received: 14 JUL 2009

Funded by

  • Medical Research Council (UK)
  • the Engineering and Physical Sciences Research Council (UK)
  • Papworth NHS Trust (UK)
  • Swedish Society for Medical Research (Sweden)
  • Wenner-Gren Foundation (Sweden)

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    Didier Belorgey, James A. Irving, Ugo I. Ekeowa, Joanna Freeke, Benoit D. Roussel, Elena Miranda, Juan Pérez, Carol V. Robinson, Stefan J. Marciniak, Damian C. Crowther, Claire H. Michel, David A. Lomas, Characterisation of serpin polymers in vitro and in vivo, Methods, 2011, 53, 3, 255

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    James A. Huntington, Masayuki Yamasaki, Serpin Structure and Evolution, 2011,

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    Sonia Caccia, Stefano Ricagno, Martino Bolognesi, Molecular bases of neuroserpin function and pathology, BioMolecular Concepts, 2010, 1, 2, 117

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