Review
You have full text access to this OnlineOpen article
Myoglobin strikes back
Article first published online: 1 DEC 2009
DOI: 10.1002/pro.300
Copyright © 2009 The Protein Society
Additional Information
How to Cite
Brunori, M. (2010), Myoglobin strikes back. Protein Science, 19: 195–201. doi: 10.1002/pro.300
Publication History
- Issue published online: 21 JAN 2010
- Article first published online: 1 DEC 2009
- Accepted manuscript online: 1 DEC 2009 12:00AM EST
- Manuscript Accepted: 12 NOV 2009
- Manuscript Revised: 11 NOV 2009
- Manuscript Received: 2 NOV 2009
Funded by
- MIUR of Italy. Grant Numbers: RBRN07BMCT_007, 20074TJ3ZB_005
References
- 1, , , , , ( 1958) A three-dimensional model of the myoglobin molecule obtained by X-ray analysis. Nature 181: 662–666.
- 2, , , ( 1959) The crystal structure of myoglobin. V. A low-resolution three-dimensional Fourier synthesis of sperm-whale myoglobin crystals. Proc R Soc Lond A 253: 70–102.
- 3, , , , , , ( 1960) Structure of myoglobin: a three-dimensional Fourier synthesis at 2 Å resolution. Nature 185: 422–427.
- 4
- 5, ( 1989) Transport of oxygen in muscle. Annu Rev Physiol 51: 857–878.
- 6, ( 2003) Myoglobin function reassessed. J Exp Biol 206: 2011–2020.
- 7, , , , , , , ( 1998) Mice without myoglobin. Nature 395: 905–908.
- 8, , , , , , ( 1999) Disruption of myoglobin in mice induces multiple compensatory mechanisms. Proc Natl Acad Sci USA 96: 10495–10500.
- 9, ( 1994) Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome c oxidase. FEBS Lett 356: 295–298.
- 10, , , , ( 1994) Reversible inhibition of cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, by nitric oxide. FEBS Lett 345: 50–54.
- 11( 1995) Nitric oxide regulates mitochondrial respiration and cell functions by inhibiting cytochrome oxidase. FEBS Lett 369: 136–139.
- 12, , ( 1995) Inhibition of cytochrome c oxidase in turnover by nitric oxide: mechanism and implications for control of respiration. Biochem J 312: 169–173.
- 13, , , , ( 1996) On the mechanism of inhibition of cytochrome c oxidase by nitric oxide. J Biol Chem 271: 33404–33408.
- 14, , , , , ( 2006) Nitric oxide and the respiratory enzyme. Biochim Biophys Acta 1757: 1144–1154.
- 15, , , ( 1998) Persistent inhibition of cell respiration by nitric oxide: crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione. Proc Natl Acad Sci USA 95: 7631–7636.
- 16( 2001) Nitric oxide, cytochrome-c oxidase and myoglobin. Trends Biochem Sci 26: 21–23.
- 17, , , , , , , , , , ( 1996) Mechanism of NO-induced oxidation of myoglobin and hemoglobin. Biochemistry 35: 6976–6983.
- 18, , , , ( 2001) Myoglobin: a scavenger of bioactive NO. Proc Natl Acad Sci USA 98: 735–740.
- 19, , ( 2008) The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics. Nat Rev Drug Discov 7: 156–167.
- 20, ( 2008) Physiology: myoglobin's new clothes. Nature 454: 416–417.
- 21, , , , , , , , , , , ( 2008) Nitrite reductase activity of myoglobin regulates respiration and cellular viability in myocardial ischemia-reperfusion injury. Proc Natl Acad Sci USA 105: 10256–10261.
- 22, , , , , , , , , ( 2008) Nitrite anion provides potent cytoprotective and antiapoptotic effects as adjunctive therapy to reperfusion for acute myocardial infarction. Circulation 117: 2986–2994.
- 23, , , , , , , , , ( 2009) Nitrite therapy after cardiac arrest reduces reactive oxygen species generation, improves cardiac and neurological function, and enhances survival via reversible inhibition of mitochondrial complex I. Circulation 120: 897–905.
- 24, ( 1971) Hemoglobin and myoglobin in their reactions with ligands. Amsterdam, The Netherlands: North Holland Publishing Co.
- 25( 1989) Hemoproteins, ligands, quanta. J Biol Chem 264: 20155–20158.
- 26, ( 1966) An X-ray study of azide methaemoglobin. J Mol Biol 21: 199–207.
- 27, , ( 2001) Mapping the pathways for O2 entry into and exit from myoglobin. J Biol Chem 276: 5177–5188.
- 28, , ( 1989) Electrostatic interactions in wild-type and mutant recombinant human myoglobins. Biochemistry 28: 3771–3781.
- 29, ( 1990) Enhanced sampling in molecular dynamics: use of time-dependent Hartree approximation for a simulation of carbon-monoxide diffusion through myoglobin. J Am Chem Soc 112: 9161–9175.
- 30, , , , ( 1975) Dynamics of ligand binding to myoglobin. Biochemistry 14: 5355–5373.
- 31, , , ( 1983) Nanosecond absorption spectroscopy of hemoglobin: elementary processes in kinetic cooperativity. Proc Natl Acad Sci USA 80: 2235–2239.
- 32, , , , , , , , , , , , , , , , ( 1991) Ligand binding to heme proteins: connection between dynamics and function. Biochemistry 30: 3988–4001.
- 33, , , , , ( 1992) Speed of intersubunit communication in proteins. Biochemistry 31: 6692–6702.
- 34, , , , ( 1994) Conformational relaxation and ligand binding in myoglobin. Biochemistry 33: 5128–5145.
- 35, , , ( 1994) Crystal structure of photolysed carbonmonoxy-myoglobin. Nature 371: 808–812.
- 36, , ( 1997) Initial trajectory of carbon monoxide after photodissociation from myoglobin at cryogenic temperatures. Biochemistry 36: 12087–12100.
- 37, , , ( 2000) Ligand binding and conformational motions in myoglobin. Nature 404: 205–208.
- 38, , , , , , , ( 2000) The role of cavities in protein dynamics: crystal structure of a photolytic intermediate of a mutant myoglobin. Proc Natl Acad Sci USA 97: 2058–2063.
- 39, ( 2000) Trapping intermediates in the crystal: ligand binding to myoglobin. Curr Opin Struct Biol 10: 744–752.
- 40, , , , , , , , , ( 1996) Photolysis of the carbon monoxide complex of myoglobin: nanosecond time-resolved crystallography. Science 274: 1726–1729.
- 41, , ( 2004) Analytical trapping: extraction of time-independent structures from time-dependent crystallographic data. J Struct Biol 147: 211–222.
- 42, , ( 2008) Structural dynamics of myoglobin. Methods Enzymol 437: 397–416.
- 43, , , , , ( 1999) Structural dynamics of ligand diffusion in the protein matrix: a study on a new myoglobin mutant Y(B10) Q(E7) R(E10). Biophys J 76: 1259–1269.
- 44, , , , , , ( 2006) Extended subnanosecond structural dynamics of myoglobin revealed by Laue crystallography. Proc Natl Acad Sci USA 103: 4924–4929.
- 45, , , , , , , , , ( 2001) Protein conformational relaxation and ligand migration in myoglobin: a nanosecond to millisecond molecular movie from time-resolved Laue X-ray diffraction. Biochemistry 401: 3802–3815.
- 46, , , , , , , , ( 2003) Complex landscape of protein structural dynamics unveiled by nanosecond Laue crystallography. Proc Natl Acad Sci USA 100: 8704–8709.
- 47, , , , , , , , ( 2003) Watching a protein as it functions with 150-ps time-resolved X-ray crystallography. Science 300: 1944–1947.
- 48, , , , , , , ( 2005) Ligand migration pathway and protein dynamics in myoglobin: a time-resolved crystallographic study on L29W MbCO. Proc Natl Acad Sci USA 102: 11704–11709.
- 49, , ( 1993) Nonexponential protein relaxation: dynamics of conformational change in myoglobin. Proc Natl Acad Sci USA 90: 5801–5804.
- 50, , , , , , , ( 1985) Protein states and proteinquakes. Proc Natl Acad Sci USA 82: 5000–5004.
- 51, , ( 2003) Myoglobin: the hydrogen atom of biology and a paradigm of complexity. Proc Natl Acad Sci USA 100: 8615–8617.
- 52, ( 1997) Ligand migration in sperm whale myoglobin. Biochemistry 36: 11909–11917.
- 53, , ( 1991) The energy landscapes and motions of proteins. Science 254: 1598–1603.
- 54, ( 1996) Non-exponential structural relaxations in proteins. J Chem Phys 104: 3395–3398.
- 55, , ( 2004) Unveiling functional protein motions with picosecond X-ray crystallography and molecular dynamics simulations. Proc Natl Acad Sci USA 101: 15330–15334.
- 56, , , , , , ( 2005) Molecular dynamics simulation of sperm whale myoglobin: effects of mutations and trapped CO on the structure and dynamics of cavities. Biophys J 89: 465–474.

1469-896X/asset/olbannerleft.gif?v=1&s=d218899ae53b2862ab119790ed504b8d72122fb3)
1469-896X/asset/olbannerright.gif?v=1&s=59470eb9a1d9b7b13b1be75e9445e6c46ee2214f)
