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Human tissue transglutaminase is inhibited by pharmacologic and chemical acetylation
Article first published online: 8 DEC 2009
DOI: 10.1002/pro.301
Copyright © 2009 The Protein Society
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How to Cite
Lai, T. S., Davies, C. and Greenberg, C. S. (2010), Human tissue transglutaminase is inhibited by pharmacologic and chemical acetylation. Protein Science, 19: 229–235. doi: 10.1002/pro.301
Publication History
- Issue published online: 21 JAN 2010
- Article first published online: 8 DEC 2009
- Accepted manuscript online: 8 DEC 2009 12:00AM EST
- Manuscript Accepted: 27 NOV 2009
- Manuscript Revised: 29 SEP 2009
- Manuscript Received: 12 AUG 2009
Funded by
- NIH. Grant Numbers: HL072184, NS050541
References
- 1( 1983) Mechanism and basis for specificity of transglutaminase-catalyzed epsilon-(gamma-glutamyl) lysine bond formation. Advam Enzymol Rel Areas Mol Biol 54: 1–56.
- 2, ( 2003) Transglutaminases: crosslinking enzymes with pleiotropic functions. Nature Rev 4: 140–156.
- 3, , ( 1991) Transglutaminases: multifunctional cross-linking enzymes that stabilize tissues. FASEB J 5: 3071–3077.
- 4, , ( 2008) Tissue transglutaminase: a novel pharmacological target in preventing toxic protein aggregation in neurodegenerative diseases. Eur J Pharmacol 585: 464–472.
- 5, , , , , , , , , , ( 2002) ‘Tissue’ transglutaminase ablation reduces neuronal death and prolongs survival in a mouse model of Huntington's disease. Cell Death Differ 9: 873–880.
- 6, ( 2005) Tissue transglutaminase contributes to disease progression in the R6/2 Huntington's disease mouse model via aggregate-independent mechanisms. J Neurochem 92: 83–92.Direct Link:
- 7, , , , , , , , , , , ( 2002) Therapeutic effects of cystamine in a murine model of Huntington's disease. J Neurosci 22: 8942–8950.
- 8, , , , ( 2005) Mechanism for the inhibition of transglutaminase 2 by cystamine. Biochem Pharmacol 69: 961–970.
- 9, , , , , , , ( 2002) Prolonged survival and decreased abnormal movements in transgenic model of Huntington disease, with administration of the transglutaminase inhibitor cystamine. Nat Med 8: 143–149.
- 10, , , , ( 2004) Effect of tissue transglutaminase on the solubility of proteins containing expanded polyglutamine repeats. J Neurochem 88: 1253–1260.Direct Link:
- 11, , , , , ( 2008) Tissue transglutaminase modulates alpha-synuclein oligomerization. Protein Sci 17: 1395–1402.Direct Link:
- 12, , , , , ( 2005) Covalent blocking of fibril formation and aggregation of intracellular amyloidgenic proteins by transglutaminase-catalyzed intramolecular cross-linking. Biochemistry 44: 2072–2079.
- 13, , ( 1999) Tau is modified by tissue transglutaminase in situ: possible functional and metabolic effects of polyamination. J Neurochem 73: 1871–1880.
- 14, , , , , , , , ( 2008) Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug libraries. Chem Biol 15: 969–978.
- 15, , , ( 2003) Design, synthesis, and evaluation of gluten peptide analogs as selective inhibitors of human tissue transglutaminase. Chem Biol 10: 225–231.
- 16, ( 1992) Post-translational chemical modification(s) of proteins. Int J Biochem 24: 19–28.
- 17, , , ( 1995) Surface lysine residues modulate the collisional transfer of fatty acid from adipocyte fatty acid binding protein to membranes. Biochemistry 34: 11840–11845.
- 18, ( 2003) Regulating the regulators: Lysine modifications make their mark. Cell 112: 11–17.
- 19, , , ( 1992) A microtiter plate transglutaminase assay utilizing 5-(biotinamido)pentylamine as substrate. Analyt Biochem 205: 166–171.
- 20, , , ( 2004) Mapping of factor XIII solvent accessibility as a function of activation state using chemical modification methods. Biochemistry 43: 9755–9765.
- 21, , , , ( 2004) Probing rhodopsin-transducin interactions by surface modification and mass spectrometry. Biochemistry 43: 11153–11162.
- 22, ( 1986) Acetylation of antithrombin III by aspirin. Semin Thromb Hemost 12: 213–215.
- 23, , ( 1999) Acetylation of human hemoglobin by methyl acetylphosphate. Evidence of broad regio-selectivity revealed by NMR studies. J Biol Chem 274: 26629–26632.
- 24, , , ( 1999) NMR study of the sites of human hemoglobin acetylated by aspirin. Biochim Biophys Acta 1432: 333–349.
- 25, , , , ( 2001) Modified clotting properties of fibrinogen in the presence of acetylsalicylic acid in a purified system. Ann NY Acad Sci 936: 531–535.
- 26( 1976) Lysine residue 199 of human serum albumin is modified by acetylsalicyclic acid. FEBS Lett 66: 173–175.
- 27, ( 1993) Hydrolysis and stability of acetylsalicylic acid in stearylamine-containing liposomes. J Pharm Pharmacol 45: 496–499.
- 28, ( 2008) Transglutaminase-catalyzed post-translational modifications of proteins in the nervous system and their possible involvement in neurodegenerative diseases. CNS Neurol Disord Drug Targets 7: 370–375.
- 29, ( 2007) Transglutaminase 2 inhibitors and their therapeutic role in disease states. Pharm Therap 115: 232–245.
- 30, , , , ( 1985) Hydrophobicity of amino acid residues in globular proteins. Science 229: 834–838.
- 31, ( 1994) Protein footprinting by the combined use of reversible and irreversible lysine modifications. Proc Natl Acad Sci USA 91: 11904–11908.
- 32, ( 2008) Lysine acetylation: codified crosstalk with other posttranslational modifications. Mol Cell 31: 449–461.
- 33
- 34, , ( 2002) Structural basis for the guanine nucleotide-binding activity of tissue transglutaminase and its regulation of transamidation activity. Proc Natl Acad Sci USA 99: 2743–2747.
- 35( 1991) MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures. J Appl Cryst 24: 946–950.Direct Link:
- 36, ( 1994) Raster3D Version 2.0. A program for photorealistic molecular graphics. Acta Cryst D 50: 869–873.Direct Link:
- 37, , , ( 2007) Transglutaminase 2 undergoes a large conformational change upon activation. PLoS Biol 5: e327.
- 38, ( 2008) Nonsteroidal anti-inflammatory drugs in experimental parkinsonian models and Parkinson's disease. Curr Pharm Des 14: 1428–1434.
- 39, , , ( 1972) Absorption kinetics of aspirin in man following oral administration of an aqueous solution. J Pharm Sci 61: 379–385.Direct Link:
- 40( 2008) An aspirin a day for Alzheimer's disease? Lancet Neurol 7: 20–21.
- 41, , , , , , , , ( 2004) Anti-inflammatory treatment with acetylsalicylate or rofecoxib is not neuroprotective in Huntington's disease transgenic mice. Neurobiol Dis 17: 319–325.
- 42, , , , ( 1998) Regulation of human tissue transglutaminase function by magnesium-nucleotide complexes. Identification of distinct binding sites for Mg- GTP and Mg-ATP. J Biol Chem 273: 1776–1781.
- 43, , , ( 1999) Probability-based protein identification by searching sequence databases using mass spectrometry data. Electrophoresis 20: 3551–3567.Direct Link:

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