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Osmolytes modulate conformational exchange in solvent-exposed regions of membrane proteins

  1. Ricardo H. Flores Jiménez,
  2. Marie-Ange Do Cao,
  3. Miyeon Kim†,
  4. David S. Cafiso*

Article first published online: 10 DEC 2009

DOI: 10.1002/pro.305

Issue

Protein Science

Protein Science

Volume 19, Issue 2, pages 269–278, February 2010

Additional Information

How to Cite

Flores Jiménez, R. H., Do Cao, M.-A., Kim, M. and Cafiso, D. S. (2010), Osmolytes modulate conformational exchange in solvent-exposed regions of membrane proteins. Protein Science, 19: 269–278. doi: 10.1002/pro.305

Author Information

  1. Department of Chemistry and Biophysics Program, University of Virginia, Charlottesville, Virginia

  1. †

    The Jules Stein Eye Institute, UCLA school of Medicine, Los Angeles, CA 90095

*Department of Chemistry, McCormick Road University of Virginia, Charlottesville, VA 22904-4319

Publication History

  1. Issue published online: 21 JAN 2010
  2. Article first published online: 10 DEC 2009
  3. Accepted manuscript online: 10 DEC 2009 12:00AM EST
  4. Manuscript Accepted: 4 DEC 2009
  5. Manuscript Revised: 18 NOV 2009
  6. Manuscript Received: 23 SEP 2009

Funded by

  • National Institutes of Health, NIGMS. Grant Number: GM 035215

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  1. 1
    Ricardo H. Flores Jiménez, Daniel M. Freed, David S. Cafiso, Lipid and Membrane Mimetic Environments Modulate Spin Label Side Chain Configuration in the Outer Membrane Protein A, The Journal of Physical Chemistry B, 2011, 115, 49, 14822

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  2. 2
    Hassane S. Mchaourab, P. Ryan Steed, Kelli Kazmier, Toward the Fourth Dimension of Membrane Protein Structure: Insight into Dynamics from Spin-Labeling EPR Spectroscopy, Structure, 2011, 19, 11, 1549

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    Daniel M. Freed, Peter S. Horanyi, Michael C. Wiener, David S. Cafiso, Conformational Exchange in a Membrane Transport Protein Is Altered in Protein Crystals, Biophysical Journal, 2010, 99, 5, 1604

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