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Aggregation of a multidomain protein: A coagulation mechanism governs aggregation of a model IgG1 antibody under weak thermal stress

  1. Christian Beyschau Andersen1,2,
  2. Mauro Manno1,
  3. Christian Rischel2,†,
  4. Matthías Thórólfsson2,†,
  5. Vincenzo Martorana1,*

Article first published online: 15 DEC 2009

DOI: 10.1002/pro.309

Issue

Protein Science

Protein Science

Volume 19, Issue 2, pages 279–290, February 2010

Additional Information

How to Cite

Andersen, C. B., Manno, M., Rischel, C., Thórólfsson, M. and Martorana, V. (2010), Aggregation of a multidomain protein: A coagulation mechanism governs aggregation of a model IgG1 antibody under weak thermal stress. Protein Science, 19: 279–290. doi: 10.1002/pro.309

Author Information

  1. 1

    Institute of Biophysics, National Research Council, CNR, Via Ugo La Malfa 153, I-90146 Palermo, Italy

  2. 2

    Protein Structure and Biophysics, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Måløv, Denmark

  1. †

    Christian Rischel and Matthías Thórólfsson are employees of Novo Nordisk A/S, which develops, manufactures and markets therapeutic proteins.

*Institute of Biophysics, National Research Council, CNR, Via Ugo La Malfa 153, I-90146 Palermo, Italy

Publication History

  1. Issue published online: 21 JAN 2010
  2. Article first published online: 15 DEC 2009
  3. Accepted manuscript online: 15 DEC 2009 12:00AM EST
  4. Manuscript Accepted: 30 NOV 2009
  5. Manuscript Received: 7 OCT 2009

Funded by

  • Novo Nordisk International Postdoc Fellowship (C.B.A.)

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