Aggregation of a multidomain protein: A coagulation mechanism governs aggregation of a model IgG1 antibody under weak thermal stress

doi:10.1002/pro.309

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Aggregation of a multidomain protein: A coagulation mechanism governs aggregation of a model IgG1 antibody under weak thermal stress

Christian Beyschau Andersen^1,2,
Mauro Manno¹,
Christian Rischel^2,†,
Matthías Thórólfsson^2,†,
Vincenzo Martorana^1,*

Article first published online: 15 DEC 2009

DOI: 10.1002/pro.309

Issue

Protein Science

Volume 19, Issue 2, pages 279–290, February 2010

Additional Information

How to Cite

Andersen, C. B., Manno, M., Rischel, C., Thórólfsson, M. and Martorana, V. (2010), Aggregation of a multidomain protein: A coagulation mechanism governs aggregation of a model IgG1 antibody under weak thermal stress. Protein Science, 19: 279–290. doi: 10.1002/pro.309

Author Information

¹
Institute of Biophysics, National Research Council, CNR, Via Ugo La Malfa 153, I-90146 Palermo, Italy
²
Protein Structure and Biophysics, Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Måløv, Denmark

^†
Christian Rischel and Matthías Thórólfsson are employees of Novo Nordisk A/S, which develops, manufactures and markets therapeutic proteins.

Email: Vincenzo Martorana (vincenzo.martorana@cnr.it)

^*Institute of Biophysics, National Research Council, CNR, Via Ugo La Malfa 153, I-90146 Palermo, Italy

Publication History

Issue published online: 21 JAN 2010
Article first published online: 15 DEC 2009
Accepted manuscript online: 15 DEC 2009 12:00AM EST
Manuscript Accepted: 30 NOV 2009
Manuscript Received: 7 OCT 2009

Funded by

Novo Nordisk International Postdoc Fellowship (C.B.A.)

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