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The pyruvate kinase model system, a cautionary tale for the use of osmolyte perturbations to support conformational equilibria in allostery
Article first published online: 13 JUL 2010
DOI: 10.1002/pro.450
Copyright © 2010 The Protein Society
Additional Information
How to Cite
Fenton, A. W., Johnson, T. A. and Holyoak, T. (2010), The pyruvate kinase model system, a cautionary tale for the use of osmolyte perturbations to support conformational equilibria in allostery. Protein Science, 19: 1796–1800. doi: 10.1002/pro.450
Publication History
- Issue published online: 23 AUG 2010
- Article first published online: 13 JUL 2010
- Manuscript Accepted: 27 MAY 2010
- Manuscript Received: 13 APR 2010
Funded by
- NIH. Grant Number: DK78076
- National Center for Research Resources. Grant Number: P20 RR17708
References
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- 6( 2004) Quantitative analysis and interpretation of allosteric behavior. Methods Enzymol 380: 187–203.
- 7( 1972) Ligand binding and internal equilibria in proteins. Biochemistry 11: 864–878.