The internal thioester and the covalent binding properties of the complement proteins C3 and C4
Article first published online: 31 DEC 2008
Copyright © 1997 The Protein Society
Volume 6, Issue 2, pages 263–274, February 1997
How to Cite
Law, S. K. A. and Dodds, A. W. (1997), The internal thioester and the covalent binding properties of the complement proteins C3 and C4. Protein Science, 6: 263–274. doi: 10.1002/pro.5560060201
- Issue published online: 31 DEC 2008
- Article first published online: 31 DEC 2008
- Manuscript Accepted: 23 OCT 1996
- Manuscript Received: 4 SEP 1996
- 1987. Formation of covalent complexes between the fourth component of human complement and IgG immune aggregates. Complement 4: 21–32. , , , ,
- 1989. C3 binds covalently to the Cy3 domain of IgG immune aggregates during complement activation by the alternative pathway. Biochem J 257: 831–838. , , , , ,
- 1994. C3 binds with similar efficiency to Fab and Fc regions of IgG immune aggregates. Eur J Immunol 24: 599–604. , , , , ,
- 1990. Molecular basis of complement C3 deficiency in guinea pigs. 7 Clin Invest 6: 96–106. , , , .
- 1980. Inherited structural polymorphism of the fourth component of human complement. Proc Natl Acad Sci USA 77: 3576–3580. , .
- 1983. Extended HLA/complement allele haplotypes: Evidence for T/t-like complex in man. Proc Natl Acad Sci USA 80: 259–263. , , , .
- 1984. The structural basis of the multiple forms of human complement component C4. Cell 36: 907–914. , , .
- 1985. Polymorphism of human complement component C4. Immunogenetics 21: 173–180. , , , .
- 1974. Interaction between erythrocyte membrane proteins and complement components: II. The identification and peptide composition of complement components C3 and C4 desorbed from erythrocyte membranes. Biochim Biophys Acta 373: 295–307. , , , .
- 1980. The binding of human complement component C4 to antibody-antigen aggregates. Biochem J 189: 67–80. , , .
- 1981. Amino acid sequence around the thiol and reactive acyl groups of human complement component C4. Biochem J 199: 359–370. , , .
- 1993. MHC genes in autoimmunity. Curr Opin Immunol 5: 887–893. , .
- 1984. A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B. Nature 307: 237–241. , , , .
- 1990. Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A. Proc Natl Acad Sci USA 87: 6868–6872. , , , , .
- 1994. Biology of disease: a2-Macroglobulin, complement, and biologic defense: Antigens, growth factors, microbial proteases, and receptor ligation. Lab Invest 7/: 792–812. , .
- 1991. Mechanism of insulin incorporation into a2-macroglobulin: Implications for the study of peptide and growth factor binding. Biochemistry 30: 1551–1560. , , , .
- 1976. Studies on the mechanism of solubilization of immune precipitates by serum. 7 Exp Med 743: 615–630. ,
- 1966. Hemolytic activity of lipoprotein-depleted serum and the effect of certain anions on complement. J Immunol 97: 680–685. , .
- 1967. Physico-chemical characteristics of the third and fourth component of complement after dissociation from complement-cell complexes. Immunology 73: 293–305. , .
- 1985. Human complement component C3: cDNA coding sequence and derived primary structure. Proc Natl Acad Sci USA 82: 708–712. , .
- 1993. The phylogeny and evolution of the complement system. In: WhaleyK, LoosM, WeilerJM, eds. Complement in health and disease. Dordrecht/Boston/London: Kluwer Academic Publishers, pp 39–88. , .
- 1988. Structural basis of the binding specificity of the thioester-containing proteins, C4, C3 and a2-macroglobulin. Complement 5: 89–97. , .
- 1990. The complement component C4 of mammals. Biochem J 265: 495–502. , .
- 1985. The origin of the very variable hae-molytic activities of the common human complement component C4 allo-types including C4-A6. EMBO 74: 2239–2244. , , .
- 1986. The purification and properties of some less common allotypes of the fourth component of human complement. Immunogenetics 24: 279–285. , , .
- 1996. The reaction mechanism of the internal thioester in the human complement component C4. Nature 379: 177–179. , , , .
- 1983. Synthetic lactam and thiolactone models of protein metastable binding sites. Ann NY Acad Sei 427: 167–177. , .
- 1981. The binding of complement component C3 to antibody-antigen aggregates after activation of the alternative pathway in human serum. Biochem J 795: 471–480. , .
- 1976. Independent effects of IgG and complement upon human polymorphonuclear leukocyte function. 7 Immunol 7/7: 1282–1287. , , ,
- 1926. The action of ammonia on complement: The fourth component. Biochem J 20: 1028–1035. , ,
- 1979. Heat-induced fragmentation of human α2-macroglobulin. J Biol Chem 254: 8669–8678. , , .
- 1981. Sequence determination of the thiolester site of the fourth component of human complement. Proc Natl Acad Sci USA 78: 7388–7392. , , .
- 1988. Inherited deficiency of the fourth component of human complement. Immunodeficiency Rev 1: 3–22. , , .
- 1991. Re-constitution of C5 convertase of the alternative complement pathway with isolated C3b dimer and factors B and D. J Immunol 746: 1868–1873. , , , , ,
- 1982. Binding of C3b proceeds by a transesterification reaction at the thiolester site. Nature 298: 72–75. , , , .
- 1981. Reactive site in human α2-macroglobulin: Circumstantial evidence for a thiolester. Proc Natl Acad Sci USA 78: 2235–2239. .
- 1992. Structural requirements for thioester bond formation in human complement component C3. Reassessment of the role of thioester bond integrity on the conformation of C3. J Biol Chem 267: 10062–10069. , .
- 1982. Conformational and functional changes in the fourth component of human complement produced by nucleophilic modification and by proteolysis with Cls. Biochemistry 27: 1109–1117. , .
- 1981. Nucleophilic modification of human complement protein C3: Correlation of conformational changes with acquisition of C3b-like functional properties. Biochemistry 20: 4458–4467. , , , , .
- 1984. The molecular basis for the difference in immune hemolysis activity of the Chido and Rodgers isotypes of human complement component C4. 7 Immunol 732: 3019–3027. , .
- 1980a. Third component of human complement: Appearance of a sulfhydryl group following chemical or enzymatic inactivation. Biochemistry 79: 4471–4478. , , , , .
- 1980b. Third component of human complement: Structural requirements for its function. Biochemistry 79: 4479–4485. , , .
- 1969. The enhancement of bacterial phagocytosis by serum: The role of complement components and two cofactors. 7 Exp Med 729: 1275–1290. , , , .
- 1985. Nucleotide sequence of cDNA encoding human a2-macroglobulin and assignment of the chromosomal locus. Proc Natl Acad Sci USA 82: 2282–2286. , , , , ,
- 1981. Synthesis of macrocyclic peptide thiolactones as models of the metastable binding sites of a2-macroglobulin and complement protein C3b. J Am Chem Soc 703: 7374–7376. , .
- 1982. An equilibrium model of the metastable binding sites of of2-macroglobulin and complement proteins C3 and C4. J Biol Chem 257: 11864–11867. , .
- 1992. Covalent binding of C3b to C4b within the classical complement pathway C5 convertase: Determination of amino acid residues involved in ester linkage formation. J Biol Chem 267: 4171–4176. , , , , , , ,
- 1988. C5 con-vertase of the alternative complement pathway: Covalent linkage between two C3b molecules within the trimolecular complex enzyme. J Immunol 747: 3895–3901. , , , , ,
- 1990. Localization of the covalent C3b-binding site on C4b within the complement classical pathway C5 convertase, C4b2a3b. J Biol Chem 265: 14444–14449. , , , , , , , ,
- 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680–685. .
- 1993. Third component of trout complement: cDNA cloning and conservation of functional sites. J Immunol 75/: 6123–6134 , , ,
- 1977. Interaction between the third complement protein and cell surface macromolecules. Proc Natl Acad Sci USA 74: 2701–2705. , .
- 1980. Interaction between the labile binding sites of the fourth (C4) and the fifth (C5) human complement proteins and erythrocyte cell membrane. J Immunol 725: 634–639. , , , .
- 1979. Evidence for an ester linkage between the labile binding site of C3b and receptive surfaces. J Immunol 725: 1388–1394. , , .
- 1983. Non-enzymic activation of the covalent binding reaction of the complement protein C3. Biochem J 2/7: 381–389. .
- 1996. Catalysed hydrolysis-The complement quickstep. Immunology Today 77: 105. , .
- 1984a. A comparison of the properties of two classes, C4A and C4B, of the human complement component C4. EMBO J 3: 1819–1923. , , .
- 1981. Binding reaction between the third human complement protein and small molecules. Biochemistry 20: 7457–7463. , , .
- 1984b. Covalent binding efficiency of the third and fourth complement proteins in relation to pH, nucleophilicity, and availability of hydroxyl groups. Biochemistry 23: 3261–3272. , , .
- 1995. Complement, Second edition, In: MaleD, ed. In focus. Oxford, UK: IRL Press. , .
- (WHO-IUIS Nomenclature Sub-Committee). 1993. Revised nomenclature for human complement component C4. J Immunol Methods 163: 3–7. , , , , , , , , , , , , , , , , , , ,
- 1966. The reaction mechanism of βic-globulin (C3) in immune hemolysis. J Exp Med 724: 33–54. , , .
- 1967. Formation and functional significance of a molecular complex derived from the second and the fourth component of human complement. J Exp Med 725: 359–380. , , .
- 1983. Ovostatin: A novel proteinase inhibitor from chicken egg white. II. Mechanism of inhibition studied with collagenase and thermolysin. J Biol Chem 258: 7490–7498. ,
- 1983. Ovostatin: A novel proteinase inhibitor from chicken egg white. I. Purification, physicochem-ical properties, and tissue distribution of ovostatin. J Biol Chem 258: 7481–7489. , , ,
- 1974. Kinetic studies of the formation of the properdin system enzymes on zymosan: Evidence that nascent C3b controls the rate of assembly. I Immunol 112: 115–1123. , , , , .
- 1993. Evidence from sequence analysis that hen egg-white ovomacroglobulin (ovostatin) is devoid of an internal beta-Cys-gamma-Glu thiol ester. Biochim Biophys Acta 1162: 230–232. ,
- 1985. Complete nucleotide and derived amino acid sequences of the fourth component of mouse complement (C4). Evolutionary aspects. J Biol Chem 260: 10936–10943. , , ,
- 1978. Two HLA-linked loci controlling the fourth component of human complement. Proc Natl Acad Sci USA 75: 5165–5169. , ,
- 1992a. Spontaneous reformation of the intramolecular thioester in complement protein C3 and low temperature capture of a conformational intermediate capable of reformation. J Biol Chem 267: 8584–8590. .
- 1992b. Spontaneous thioester bond formation in a2-macroglobulin, C3 and C4. FEBS Lett 308: 280–282. .
- 1980. Relation of putative thioester bond in C3 to activation of the alternative pathway and the binding of C3b to biological targets of complement. J Exp Med 152: 1102–1114. , .
- 1953. The requirement for a hydrazine-sensitive serum factor and heat-labile serum factors in the inactivation of human C3 by zymosan. J Immunol 77: 339–345. , ,
- 1983. Complement polymorphism, the major histocompatibility complex and associated diseases: A speculation. Mol Biol Med /: 161–168. .
- 1985. The complement components coded in the major histocompatibility complexes and their biological activities. Immunol Rev 87: 7–17. .
- 1995. The effect of residue 1106 on the thioester-mediated covalent binding reaction of human complement protein C4 and the monomeric rat a-macroglobulin J. FEBS Lett 368: 87–91. , , , , .
- 1993. The thioester and isotypic sites of complement component C4 in sheep and cattle. Immunogenetics 37: 120–128. , , .
- 1994. Specificity of the thioester-containing reactive site of human C3 and its significance to complement activation. Biochem J 302: 429–436. , , .
- 1994. Covalent attachment of human complement C3 to IgG. Identification of the amino acid residue involved in ester linkage formation. J Biol Chem 269: 28997–29002. , .
- 1995. Tyrosine is a potential site for covalent attachment of activated complement component C3. Mol Immunol 32: 711–716. , .
- 1996. Investigation of mechanism-based inhibitors of complement targeting the activated thioester of human C3. Biochem Pharmacol 57: 797–804. , .
- 1993. Covalent binding properties of the human complement protein C4 and hydrolysis rate of the internal thioester upon activation. Protein Sei 2: 706–716. , , , , , .
- 1993. Identification of a major binding site for complement C3 on the IgGl heavy chain. J Biol Chem 268: 5866–5871. , , .
- 1981. Autolytic fragmentation of complement components C3 and C4 under denaturing conditions, a property shared with a2-macroglobulin. Biochem J 793: 129–141. ,
- 1981. The covalent-binding reaction of complement component C3. Biochem J 793: 115–127. , , ,
- 1987. α2-Macroglobulin and related thiol ester plasma proteins. In: PutnamFW, ed. The plasma proteins. Orlando, Florida: Academic Press, pp 191–291.
- 1981. Sequence location of the reactive thiol ester in human a2-macroglobulin. FEBS Lett 123: 145–148. , , , ,
- 1980. A thiol-ester in α2-macro-globulin cleaved during proteinase complex formation. FEBS Lett 121: 275–279. , ,
- 1985. Common evolutionary origin of a2-macroglobulin and complement components C3 and C4. Proc Natl Acad Sci USA 82: 9–13. , , , , , , , , , , , .
- 1975. The opsonic fragment of the third component of human complement (C3). J Exp Med 141: 1329–1347. , , , , .
- 1980. Evidence for presence of an internal thiolester bond in third component of human complement. Proc Natl Acad Sci USA 77: 5764–5768. , , , , .
- 1974. Binding of soluble immune complexes to human lymphoblastoid cells: I. Characterization of receptors for IgG Fc and complement and description of binding mechanism. J Exp Med 740: 877–894. , , .
- 1988. The esterase-like activity of covalently bound human third complement protein. Mol Immunol 25: 821–828. , .
- 1984. Natural release of covalently bound C3b from cell surfaces and the study of this phenomenon in the fluid-phase system. J Immunol 732: 1435–1439. , , , .
- 1986. Structural basis of the polymorphism of human complement components C4A and C4B: Gene size, reactivity and antigenicity. EMBO J 5: 2873–2881. , , , , .