Article
You have full text access to this OnlineOpen article
A 3D model for the measles virus receptor CD46 based on homology modeling, Monte Carlo simulations, and hemagglutinin binding studies
Article first published online: 31 DEC 2008
DOI: 10.1002/pro.5560060308
Copyright © 1997 The Protein Society
Additional Information
How to Cite
Mumenthaler, C., Schneider, U., Buchholz, C. J., Koller, D., Cattaneo, R. and Braun, W. (1997), A 3D model for the measles virus receptor CD46 based on homology modeling, Monte Carlo simulations, and hemagglutinin binding studies. Protein Science, 6: 588–597. doi: 10.1002/pro.5560060308
Publication History
- Issue published online: 31 DEC 2008
- Article first published online: 31 DEC 2008
- Manuscript Accepted: 2 DEC 1996
- Manuscript Received: 7 OCT 1996
Funded by
- Schweizerische Nationalfonds. Grant Number: 31-29343.90, 3 1-33746.92, and 31-45900.95
- National Science Foundation. Grant Number: BIR-9632326
References
- , , , , , , . 1991. Secondary structure of a complement control protein module by two-dimensional 'H NMR. Biochemistry 50: 997–1004.
- , , , , , , , . 1992. Solution structure of the fifth repeat of factor H: A second example of the complement control protein module. Biochemistry 3: 3626–3634.
- , , , , , , . 1993. Solution structure of a pair of complement modules by nuclear magnetic resonance. J Mo! Biol 252: 268–284.
- , , , , , . 1994. Decay-accelerating factor, a glycosylphosphatidylinositol-anchored complement regulatory protein, is a receptor for several echoviruses. Proc Natl AcadSci USA 97: 6245–6248.
- , , , , , . 1995. Coxsackievirus 3B adapted to growth in RD cells binds to decay-accelerating factor (CD55). J Virol 69: 1903–1906.
- , , , , , , , 1977. The Protein Data Bank: A computer-based archival file for macromolecular structures. J Mol Biol 7/2: 535–542.
- , , , . 1996. Structure and distribution of modules in extracellular proteins. Quart Rev Biophys 29: 119–167.
- , , , , , , 1996a. Selective expression of a subset of measles virus receptor competent CD46 isoforms in human brain. Virology 2/7: 349–355.
- , , , , 1996b. Cell entry by measles virus: Long hybrid receptors uncouple binding from membrane fusion. J Virol 70: 3716–3723.
- , , , , , , , . 1995. Characterization of the echovirus 7 receptor: Domains of CD55 critical for virus binding. J Virol 69: 5497–5501.
- , , , , 1996. Interactions between the ectodomains of haemagglutinin and CD46 as a primary step in measles virus entry. J Gen Virol 77: 1477–1481.
- . 1992. Ultrastructures and interactions of complement factors H and I. J Immunol 149: 2592–2599.
- , , , . 1993. The human CD46 molecule is a receptor for measles virus (Edmonston strain). Cell 75: 295–305.
- , , , 1986. Eukaryotic transient expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase. Proc Natl Acad Sci USA 53: 8122–8126.
- , , 1991. Efficient computation of three-dimensional protein structures in solution from NMR data using the program DIANA and the supporting programs CALIBA, HABAS, and GLOMSA. J Mol Biol 2/7: 517–530.
- , 1994. Pattern recognition and self-correcting distance geometry calculations applied to myohemeryfhrin. FEBS Lett 344: 147–153.
- , , , , , 1992. Structure and interactions of CD4. Cold Spring Harbor Symp Quant Biol 57: 541–548.
- , , , , , , . 1992. Structural aspects of CD4 and CD8 involvement in the cellular immune response. Cold Spring Harbor Svmp Quant Biol 57: 549–556.
- , , , , . 1989. Site-directed mutagenesis by overlap-extension using the polymerase chain reaction. Gene 77: 51–59.
- , , , , , , , , 1995. Diversity of sites for measles virus binding and for inactivation of complement C3b and C4b on membrane cofactor protein CD46. J Biol Chem 270: 15148–15152.
- , , . 1989. Disulfide bonds are localized within the short consensus repeat units of complement regulatory proteins: C4b-binding protein. Biochemistry 28: 4754–4761.
- , 1994. Phi-psi conformational pattern clustering of protein amino acid residues using the potential function method. CABIOS 10: 163–169.
- , , 1996. MOLMOL: A program for display and analysis of macromolecular structures. J Mol Graphics 74: 51–55.
- , , , . 1993. PROCHECK: A program to check the stereochemical quality of protein structures. J Appl Crystallogr 26: 283–291. Direct Link:
- , , . 1991. Membrane cofactor protein (MCP or CD46): Newest member of the regulators of complement activation gene cluster. Annu Rev Immunol 9: 431–455.
- , , , , , 1996. The N-glycan of the SCR 2 region is essential for membrane cofactor protein (CD46) to function as a measles virus receptor. J Virol 70: 4973–4977.
- , 1995. Membrane cofactor protein with different types of N-glycans can serve as measles virus receptors. Virology 2/0: 479–481.
- , , , , 1994. Binding of measles virus to membrane cofactor protein (CD46): Importance of disulfide bonds and N-glycans for the receptor function. J Virol 68: 6299–6304.
- , , , , , , , . 1995. Measles virus and C3 binding sites are distinct on membrane cofactor protein (CD46). Proc Natl Acad Sci USA 92: 2303–2307.
- , , , , . 1991. Determination of the structural basis for selective binding of Epstein-Barr virus to human complement receptor type 2. J Exp Med 774: 1299–1311.
- , , , 1987. Interior and surface of monomelic proteins. J Mol Biol 796: 641–656.
- , , , , . 1992. The human immunodeficiency virus gpl20 binding site on CD4: Delineation by quantitative equilibrium and kinetic binding studies of mutants in conjunction with a high-resolution CD4 atomic structure. J Exp Med / 76: 507–517.
- , , , , , , . 1991. Analysis of Epstein-Barr virus-binding site on complement receptor 2 (CR2/CD21) using human-mouse chimeras and peptides. J Biol Chem 266: 121173–12179.
- , , , , , . 1995. Characterization of a complement receptor 2 (CR2, CD21) ligand binding site for C3. An initial model of ligand interaction with two linked short consensus repeat modules. J Immunol / 54: 5426–5435.
- , , , , , . 1991. Inhibition of Epstein-Barr virus infection in vitro and in vivo by soluble CR2 (CD21) containing two shorts consensus repeats. J Virol 65: 3559–3565.
- , 1995a. Folding of globular proteins by energy minimization and Monte Carlo simulation with hydrophobic surface area potentials. J Mol Mod 7: 1–10.
- , 1995b. Predicting the helix packing of globular proteins by self-correcting distance geometry. Protein Sci 4: 863–871. Direct Link:
- , , , , , , 1993. Human membrane cofactor protein (CD46) acts as a cellular receptor for measles virus. J Virol 67: 6025–6032.
- , , . 1983. Energy parameters in polypeptides. 9. Updating of geometrical parameters, nonbonded interactions and hydrogen bond interactions for the naturally occurring amino acids. J Phys Chem 87: 1883–1887.
- , , , , , . 1995. Functional and structural interactions between measles virus hemagglutinin and CD46. J Virol 69: 3341–3349.
- , , 1990. The program FANTOM for energy refinement of polypeptides and proteins using a Newton-Raphson mini-mizer in torsion angle space. Biopolymers 29: 679–694. Direct Link:
- , , , 1990. Quantitative analysis of mem-brane cofactor protein (MCP) of complement. High expression of MCP on human leukaemia cell lines, which is down-regulated during cell differentiation. J Immunol 745: 238–245.
- , , , , 1994. Glycosyl-phosphatidylinositol-anchored and transmembrane forms of CD46 display similar measles virus receptor properties: Virus binding, fusion, and replication; down-regulation by hemagglutinin; and virus uptake and endocytosis for antigen presentation by major histocompatibility complex class II molecules. J Virol 65: 7891–7899.
- , 1993. Minimization of empirical energy functions in proteins including hydrophobic surface area effects. J Comp Chem 14: 510–521. Direct Link:
- , , , 1992. Construction of vaccinia virus recombinants expressing several measles virus proteins and analysis of their efficacy in vaccination of mice. J Gen Virol 7i: 359–367.
- , , , , , , , , 1995. Conformation and function of the N-linked glycan in the adhesion domain of human CD2. Science 269: 1273–1278.

1469-896X/asset/olbannerleft.gif?v=1&s=d218899ae53b2862ab119790ed504b8d72122fb3)
1469-896X/asset/olbannerright.gif?v=1&s=59470eb9a1d9b7b13b1be75e9445e6c46ee2214f)
1469-896X/asset/cover.gif?v=1&s=0ff483325083001100314f63c633a394aff24478)