Article
You have full text access to this OnlineOpen article
Aromatic L-amino acid decarboxylase: Conformational change in the flexible region around arg334 is required during the transaldimination process
Article first published online: 31 DEC 2008
DOI: 10.1002/pro.5560070816
Copyright © 1998 The Protein Society
Additional Information
How to Cite
Ishii, S., Hayashi, H., Okamoto, A. and Kagamiyama, H. (1998), Aromatic L-amino acid decarboxylase: Conformational change in the flexible region around arg334 is required during the transaldimination process. Protein Science, 7: 1802–1810. doi: 10.1002/pro.5560070816
Publication History
- Issue published online: 31 DEC 2008
- Article first published online: 31 DEC 2008
- Manuscript Accepted: 14 APR 1998
- Manuscript Received: 3 FEB 1998
References
- , , , , , , , , , . 1993. Three-dimensional structure of tyrosine phenol-lyase. Biochemisrry 32: 4195–4206.
- , , , , , . 1985. Pig cytosolic aspartate aminotransferase: The structures of the internal al-dimine, external aldimine, and ketimine and of the β subform. In: ChristenP, MetzlerDE, eds. Transaminases. New York: John Wiley and Sons. pp 138–154.
- , , 1996. Conformational changes and the role of metals in the mechanism of type II dehydroquinase from Aspergillus nidulans. Biochem J 319: 269–278.
- , , , , 1996. Crystal structure of the pyridoxal-5′-phosphate dependent cystathionine ß-lyase from Escherichia coli at 1.83 Å. J Mol Biol 262: 202–224.
- , , . 1963. The preparation and enzymatic hydrolysis of reduced and S-carboymethylated proteins. J Biol Chem 238: 622–627.
- . 1964. Method and application to human serum proteins. Ann NYAcad Sci 121: 404–427. Direct Link:
- . 1995. Omega loops: Nonregular secondary structures significant in protein function and stability. FASEB J 9: 708–717.
- , . 1993. Mutational and kinetic analysis of a mobile loop in tyrosyl-tRNA synthetase. Biochemistry 32: 13658–13663.
- 1989. Limited proteolysis of globular proteins occurs at exposed and flexible loops. In: KotykA, SkodaJ, PacesV, KostkaV, eds. Hilights of modern biochemistry. Utrecht, The Netherlands: VSP International Science Publishers. pp 1711–1726.
- , , , , , 1997. Probing the conformational state of apomyoglobin by limited proteolysis. J Mol Biol 266: 223–230.
- , , . 1995. Modeling of the spatial structure of eukaryotic ornithine decarboxylases. Protein Sci 4: 1291–1304. Direct Link:
- , , 1993. Rat liver aromatic L-amino acid decarboxylase: Spectroscopic and kinetic analysis of the coenzyme and reaction intermediates. Biochemistry. 32: 812–818.
- , , . 1994. Modeling studies of the change in conformation required cleavage of limited proteolytic sites. Protein Sci 3: 757–768. Direct Link:
- , , , , 1996. Functionally important residues of aromatic L-amino acid decarboxylase probed by sequence alignment and site-directed mutagenesis. J Biochem 120: 369–376.
- , , , , , , , , , . 1998. Crystal structure of tryptophanase. J Mol Eiol 276: 603–623.
- , , , , , 1985. Spatial structure of mitochondrial aspartate aminotransferase. In: ChristenP, MetzlerDE, eds. Transaminases. New York: John Wiley and Sons. pp 109–137.
- , , 1990. Anatomy of a conformational change: Hinged “lid” motion of the triosephosphate isomerase loop. Science 249: 1425–1428.
- , , , , , , 1994. Flexible loop that is novel catalytic machinery in a ligase. Atomic structure and function of the loopless glutathione synthetase. Biochemistry 33: 4995–4999.
- , , , . 1994. Studies on pig aldose reductase. Identification of an essential arginine in the primary and tertiary structure of the enzyme. J Biol Chem 269: 2183–2188.
- . 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680–685.
- , , . 1995. Mechanistic insights provided by deletion of a flexible loop at the active site of ribulose-1,5-bisphosphate carboxylase/oxygenase. Biochemistry 34: 4531–4537.
- , . 1990. Crystallographic analysis of the complex between triosephosphate isomerase and 2-phosphoglycolate at 2.5 Å resolution: Implications for catalysis. Biochemistry 29: 6619–6625.
- , . 1983. Use of radiolabeled monofluoromethyl-Dopa to define the subunit structure of human L-dopa decarboxylase. Biochemistry 22: 6058–6063.
- , . 1987. Quantitative description of absorption spectra of a pyridoxal phosphate-dependent enzyme using lognormal distribution curves. Anal Biochem 166: 313–327.
- , , , , . 1995a. Crystallographic structure of a PLP-dependent ornithine decarboxylase from Lactobacillus 30a to 3.0 Å resolution. J Mol Biol 252: 643–655.
- , , . 1995b. Structural motifs for pyridoxal-5′-phosphate binding in decarboxylases: An analysis based on the crystal structure of the Lacrobacillus 30a ornithine decarboxylase. Prorein Sei 4: 849–854.
- , . 1948. A kinetic study of alkylation by ethyl arylsulfonates. J Am Chem Soc 70: 375–377.
- , . 1970. Methylation of histidine-57 in alpha-chymotrypsin by methyl p-nitrobenzenesulfonate. A new approach to enzyme modification. Biochemisty 9: 259–267.
- , . 1987. Correlation among sites of limited proteolysis, enzyme accessibility and segmental mobility. FEBS Lett 211: 185–189.
- , , 1994. Multiple evolutionary origin of pyridoxal-5′-phosphate-dependent amino acid decarboxylases. Eur J Biochem 221: 997–1002. Direct Link:
- , , , , 1998. Crystal structure of human recombinant ornithine aminotransferase. J Mol Biol 277: 81–102.
- , , , , , , , , , . 1985. Measurement of protein using bicinchoninic acid [Erratum. Anal Biochem 163(1):279]. Anal Biochem 150: 76–85.
- , , , , , , , , 1989. Molecular cloning and sequencing of a cDNA of rat dopa decarboxylase: Partial amino acid homologies with other enzymes synthesizing catecholamines. Proc Natl Acad Sci USA 86: 8142–8146.
- , , , 1992. Mutational and proteolytic studies on a flexible loop in glutathione synthetase from Escherichia coli B: The loop and arginine 233 are critical for the catalytic reaction. Biochernistry 31: 2259–2265.
- , , , , , . 1988. Limited tryptic proteolysis of pig kidney 3,4-dihydroxyphenylalanine decarboxylase. Arch Eiochem Biophys 260: 569–576.
- , , , . 1995. Structural and mechanistic analysis of two refined crystal structures of the pyridoxal phosphate-dependent enzyme dialkylglycine decarboxylase. J Mol Biol 245: 151–179.
- , , 1987. Aromatic-L-amino acid decarboxylase from pig kidney. Methods Enzymol 142: 179–187.
- , , , , , , , , , 1989. Crystal structure analysis of ω-amino acid:pyruvate aminotransferase with a newly developed Wessenberg camera and an imaging plate using synchrotron radiation. J Biochem 105: 1–3.
- , , , , , , , 1996. Probing the tertiary structure of proteins by limited proteolysis and mass spectrometry: The case of Minibody. Protein Sci 5: 802–813. Direct Link:

1469-896X/asset/olbannerleft.gif?v=1&s=d218899ae53b2862ab119790ed504b8d72122fb3)
1469-896X/asset/olbannerright.gif?v=1&s=59470eb9a1d9b7b13b1be75e9445e6c46ee2214f)
1469-896X/asset/cover.gif?v=1&s=0ff483325083001100314f63c633a394aff24478)