1479 Cleavage of cellulose by a CBM33 protein
Zarah Forsberg, Gustav Vaaje-Kolstad, Bjørge Westereng, Anne C. Bunæs, Yngve Stenstrøm, Alasdair MacKenzie, Morten Sørlie, Svein J. Horn, and Vincent G.H. Eijsink
The discovery of novel enzymes for the conversion of lignocellulosic biomass is of great biotechnological interest. Forsberg et al. describe such a novel enzyme, which is called CelS2 and classified as a CBM33 (Carbohydrate-Binding-Module 33). It is shown that CelS2 is a metal-dependent enzyme that cleaves crystalline cellulose, while oxidizing one of the newly generated chain ends. By doing so CelS2 boosts the activity of classical cellulases.