Article
You have full text access to this OnlineOpen article
Redesign of a protein–peptide interaction: Characterization and applications
Article first published online: 12 FEB 2009
DOI: 10.1002/pro.75
Copyright © 2009 The Protein Society
Additional Information
How to Cite
Jackrel, M. E., Valverde, R. and Regan, L. (2009), Redesign of a protein–peptide interaction: Characterization and applications. Protein Science, 18: 762–774. doi: 10.1002/pro.75
Publication History
- Issue published online: 25 MAR 2009
- Article first published online: 12 FEB 2009
- Accepted manuscript online: 12 FEB 2009 12:00AM EST
- Manuscript Accepted: 28 JAN 2009
- Manuscript Revised: 19 JAN 2009
- Manuscript Received: 2 DEC 2008
Funded by
- NIH. Grant Number: GM080515
- HFSP. Grant Number: RGP44/2007
References
- 1, ( 2005) Engineering novel binding proteins from nonimmunoglobulin domains. Nat Biotechnol 23: 1257–1268.
- 2, ( 2005) Engineered proteins as specific binding reagents. Curr Opin Biotechnol 16: 459–469.
- 3, , , , , , , ( 2000) Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine. Cell 101: 199–210.
- 4, , , , , , , , , ( 2001) Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design. Science 293: 1155–1159.
- 5, , ( 1995) Tetratrico peptide repeat interactions: to TPR or not to TPR? Trends Biochem Sci 20: 257–259.
- 6, , ( 1998) The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions. Embo J 17: 1192–1199.
- 7, ( 2006) Ligand binding by TPR domains. Protein Sci 15: 1193–1198.Direct Link:
- 8, , , , ( 2004) Protein design to understand peptide ligand recognition by tetratricopeptide repeat proteins. Protein Eng Des Sel 17: 399–409.
- 9, , ( 2008) Designed TPR modules as novel anticancer agents. ACS Chem Biol 3: 161–166.
- 10( 1976) The nature of the accessible and buried surfaces in proteins. J Mol Biol 105: 1–12.
- 11( 1977) Areas, volumes, packing and protein structure. Annu Rev Biophys Bioeng 6: 151–176.
- 12, ( 1986) The role of solvent polarity in the free energy of transfer of amino acid side chains from water to organic solvents. J Biol Chem 261: 7220–7222.
- 13, ( 1986) Solvation energy in protein folding and binding. Nature 319: 199–203.
- 14, , ( 1989) Energetics of complementary side-chain packing in a protein hydrophobic core. Biochemistry 28: 4914–4922.
- 15, , , , , , ( 1992) Response of a protein structure to cavity-creating mutations and its relation to the hydrophobic effect. Science 255: 178–183.
- 16, ( 1997) Solvation: how to obtain microscopic energies from partitioning and solvation experiments. Annu Rev Biophys Biomol Struct 26: 425–459.
- 17, , , , , , , ( 2002) Ligand discrimination by TPR domains. Relevance and selectivity of EEVD-recognition in Hsp70 x Hop x Hsp90 complexes. J Biol Chem 277: 19265–19275.
- 18, ( 1998) Exact and efficient analytical calculation of the accessible surface areas and their gradients for macromolecules. J Comp Chem 19: 319–333.Direct Link:
- 19, , , , ( 1996) Construction of a fusion protein between protein A and green fluorescent protein and its application to western blotting. FEBS Lett 384: 193–197.
- 20, , , ( 2000) A flexible single-step detection of blotted antigen using a fusion protein between protein A and green fluorescent protein. Biosci Biotechnol Biochem 64: 1547–1551.
- 21( 2007) Alternative non-antibody scaffolds for molecular recognition. Curr Opin Biotechnol 18: 295–304.
- 22, , ( 2000) Selection and application of peptide-binding peptides. Nat Biotechnol 18: 71–74.
- 23
- 24, , , ( 2002) Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells. Science 296: 913–916.
- 25, , , , ( 1995) How to measure and predict the molar absorption coefficient of a protein. Protein Sci 4: 2411–2423.Direct Link:
- 26, ( 1997) Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol 276: 307–326.
- 27Collaborative Computational Project, Number 4 ( 1994) The CCP4 suite: programs for protein crystallography. Acta Crystallogr D Biol Crystallogr 50: 760–763.Direct Link:
- 28, , , , , , , , , , , , , ( 1998) Crystallography & NMR system: a new software suite for macromolecular structure determination. Acta Crystallogr D Biol Crystallogr 54: 905–921.Direct Link:
- 29
- 30, ( 2004) Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr 60: 2126–2132.Direct Link:
- 31, ( 2006) Optimal description of a protein structure in terms of multiple groups undergoing TLS motion. Acta Crystallogr D Biol Crystallogr 62: 439–450.Direct Link:

1469-896X/asset/olbannerleft.gif?v=1&s=d218899ae53b2862ab119790ed504b8d72122fb3)
1469-896X/asset/olbannerright.gif?v=1&s=59470eb9a1d9b7b13b1be75e9445e6c46ee2214f)
