SEARCH

SEARCH BY CITATION

References

  • 1
    McClatchey AI, Giovannini M ( 2005) Membrane organization and tumorigenesis—the NF2 tumor suppressor, Merlin. Genes Dev 19: 22652277.
  • 2
    Stemmer-Rachamimov AO, Xu L, Gonzalez-Agosti C, Burwick JA, Pinney D, Beauchamp R, Jacoby LB, Gusella JF, Ramesh V, Louis DN ( 1997) Universal absence of merlin, but not other ERM family members, in schwannomas. Am J Pathol 151: 16491654.
  • 3
    Ruttledge MH, Sarrazin J, Rangaratnam S, Phelan CM, Twist E, Merel P, Delattre O, Thomas G, Nordenskjold M, Collins VP, Dumanski JP, Rouleau GA ( 1994) Evidence for the complete inactivation of the NF2 gene in the majority of sporadic meningiomas. Nat Genet 6: 180184.
  • 4
    Bianchi AB, Mitsunaga SI, Cheng JQ, Klein WM, Jhanwar SC, Seizinger B, Kley N, Klein-Szanto AJ, Testa JR ( 1995) High frequency of inactivating mutations in the neurofibromatosis type 2 gene (NF2) in primary malignant mesotheliomas. Proc Natl Acad Sci USA 92: 1085410858.
  • 5
    Giovannini M, Robanus-Maandag E, van der Valk M, Niwa-Kawakita M, Abramowski V, Goutebroze L, Woodruff JM, Berns A, Thomas G ( 2000) Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2. Genes Dev 14: 16171630.
  • 6
    McClatchey AI, Saotome I, Mercer K, Crowley D, Gusella JF, Bronson RT, Jacks T ( 1998) Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors. Genes Dev 12: 11211133.
  • 7
    Lallemand D, Curto M, Saotome I, Giovannini M, McClatchey AI ( 2003) NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions. Genes Dev 17: 10901100.
  • 8
    Curto M, Cole BK, Lallemand D, Liu CH, McClatchey AI ( 2007) Contact-dependent inhibition of EGFR signaling by Nf2/Merlin. J Cell Biol 177: 893903.
  • 9
    Maitra S, Kulikauskas RM, Gavilan H, Fehon RG ( 2006) The tumor suppressors Merlin and expanded function cooperatively to modulate receptor endocytosis and signaling. Curr Biol 16: 702709.
  • 10
    Brault E, Gautreau A, Lamarine M, Callebaut I, Thomas G, Goutebroze L ( 2001) Normal membrane localization and actin association of the NF2 tumor suppressor protein are dependent on folding of its N-terminal domain. J Cell Sci 114: 19011912.
  • 11
    James MF, Manchanda N, Gonzalez-Agosti C, Hartwig JH, Ramesh V ( 2001) The neurofibromatosis 2 protein product merlin selectively binds F-actin but not G-actin, and stabilizes the filaments through a lateral association. Biochem J 356: 377386.
  • 12
    Xu HM, Gutmann DH ( 1998) Merlin differentially associates with the microtubule and actin cytoskeleton. J Neurosci Res 51: 403415.
  • 13
    Bretscher A, Edwards K, Fehon RG ( 2002) ERM proteins and merlin: integrators at the cell cortex. Nat Rev Mol Cell Biol 3: 586599.
  • 14
    Curto M, McClatchey AI ( 2008) Nf2/Merlin: a coordinator of receptor signalling and intercellular contact. Br J Cancer 98: 256262.
  • 15
    Pearson MA, Reczek D, Bretscher A, Karplus PA ( 2000) Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain. Cell 101: 259270.
  • 16
    Smith WJ, Nassar N, Bretscher A, Cerione RA, Karplus PA ( 2003) Structure of the active N-terminal domain of Ezrin. Conformational and mobility changes identify keystone interactions. J Biol Chem 278: 49494956.
  • 17
    Kang BS, Cooper DR, Devedjiev Y, Derewenda U, Derewenda ZS ( 2002) The structure of the FERM domain of merlin, the neurofibromatosis type 2 gene product. Acta Crystallogr D Biol Crystallogr 58: 381391.
  • 18
    Shimizu T, Seto A, Maita N, Hamada K, Tsukita S, Hakoshima T ( 2002) Structural basis for neurofibromatosis type 2. Crystal structure of the merlin FERM domain. J Biol Chem 277: 1033210336.
  • 19
    Edwards SD, Keep NH ( 2001) The 2.7 A crystal structure of the activated FERM domain of moesin: an analysis of structural changes on activation. Biochemistry 40: 70617068.
  • 20
    Matsui T, Maeda M, Doi Y, Yonemura S, Amano M, Kaibuchi K, Tsukita S ( 1998) Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association. J Cell Biol 140: 647657.
  • 21
    Shaw RJ, Paez JG, Curto M, Yaktine A, Pruitt WM, Saotome I, O'Bryan JP, Gupta V, Ratner N, Der CJ, Jacks T, McClatchey AI ( 2001) The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling. Dev Cell 1: 6372.
  • 22
    Hamada K, Shimizu T, Yonemura S, Tsukita S, Hakoshima T ( 2003) Structural basis of adhesion-molecule recognition by ERM proteins revealed by the crystal structure of the radixin-ICAM-2 complex. EMBO J 22: 502514.
  • 23
    Terawaki S, Maesaki R, Okada K, Hakoshima T ( 2003) Crystallographic characterization of the radixin FERM domain bound to the C-terminal region of the human Na+/H+-exchanger regulatory factor (NHERF). Acta Crystallogr D Biol Crystallogr 59: 177179.
  • 24
    Matsui T, Yonemura S, Tsukita S ( 1999) Activation of ERM proteins in vivo by Rho involves phosphatidyl-inositol 4-phosphate 5-kinase and not ROCK kinases. Curr Biol 9: 12591262.
  • 25
    Fievet BT, Gautreau A, Roy C, Del Maestro L, Mangeat P, Louvard D, Arpin M ( 2004) Phosphoinositide binding and phosphorylation act sequentially in the activation mechanism of ezrin. J Cell Biol 164: 653659.
  • 26
    Laulajainen M, Muranen T, Carpen O, Gronholm M ( 2008) Protein kinase A-mediated phosphorylation of the NF2 tumor suppressor protein merlin at serine 10 affects the actin cytoskeleton. Oncogene 27: 32333243.
  • 27
    Rong R, Surace EI, Haipek CA, Gutmann DH, Ye K ( 2004) Serine 518 phosphorylation modulates merlin intramolecular association and binding to critical effectors important for NF2 growth suppression. Oncogene 23: 84478454.
  • 28
    Alfthan K, Heiska L, Gronholm M, Renkema GH, Carpen O ( 2004) Cyclic AMP-dependent protein kinase phosphorylates merlin at serine 518 independently of p21-activated kinase and promotes merlin-ezrin heterodimerization. J Biol Chem 279: 1855918566.
  • 29
    Nguyen R, Reczek D, Bretscher A ( 2001) Hierarchy of merlin and ezrin N- and C-terminal domain interactions in homo- and heterotypic associations and their relationship to binding of scaffolding proteins EBP50 and E3KARP. J Biol Chem 276: 76217629.
  • 30
    Murthy A, Gonzalez-Agosti C, Cordero E, Pinney D, Candia C, Solomon F, Gusella J, Ramesh V ( 1998) NHE-RF, a regulatory cofactor for Na(+)-H+ exchange, is a common interactor for merlin and ERM (MERM) proteins. J Biol Chem 273: 12731276.
  • 31
    Morrison H, Sherman LS, Legg J, Banine F, Isacke C, Haipek CA, Gutmann DH, Ponta H, Herrlich P ( 2001) The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44. Genes Dev 15: 968980.
  • 32
    Hamada K, Shimizu T, Matsui T, Tsukita S, Hakoshima T ( 2000) Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain. EMBO J 19: 44494462.
  • 33
    Li Q, Nance MR, Kulikauskas R, Nyberg K, Fehon R, Karplus PA, Bretscher A, Tesmer JJ ( 2007) Self-masking in an intact ERM-merlin protein: an active role for the central alpha-helical domain. J Mol Biol 365: 14461459.
  • 34
    Scoles DR, Huynh DP, Morcos PA, Coulsell ER, Robinson NG, Tamanoi F, Pulst SM ( 1998) Neurofibromatosis 2 tumour suppressor schwannomin interacts with betaII-spectrin. Nat Genet 18: 354359.
  • 35
    Gutmann DH, Geist RT, Xu H, Kim JS, Saporito-Irwin S ( 1998) Defects in neurofibromatosis 2 protein function can arise at multiple levels. Hum Mol Genet 7: 335345.
  • 36
    Stokowski RP, Cox DR ( 2000) Functional analysis of the neurofibromatosis type 2 protein by means of disease-causing point mutations. Am J Hum Genet 66: 873891.
  • 37
    Lawrence MC, Colman PM ( 1993) Shape complementarity at protein/protein interfaces. J Mol Biol 234: 946950.
  • 38
    Lallemand D, Saint-Amaux AL, Giovannini M ( 2009) Tumor-suppression functions of merlin are independent of its role as an organizer of the actin cytoskeleton in Schwann cells. J Cell Sci 122: 41414149.
  • 39
    LaJeunesse DR, McCartney BM, Fehon RG ( 1998) Structural analysis of Drosophila merlin reveals functional domains important for growth control and subcellular localization. J Cell Biol 141: 15891599.
  • 40
    Kitano K, Yusa F, Hakoshima T ( 2006) Structure of dimerized radixin FERM domain suggests a novel masking motif in C-terminal residues 295–304. Acta Crystallogr Sect F Struct Biol Cryst Commun 62: 340345.
  • 41
    Henrick K, Thornton JM ( 1998) PQS: a protein quaternary structure file server. Trends Biochem Sci 23: 358361.
  • 42
    Janin J, Rodier F ( 1995) Protein-protein interaction at crystal contacts. Proteins 23: 580587.
  • 43
    Vonrhein C, Flensburg C, Keller P, Sharff A, Smart O, Paciorek W, Womack T, Bricogne G ( 2011) Data processing and analysis with teh autoPROC toolbox. Acta Crystallogr D Biol Crystallogr 67: 293302.
  • 44
    Kabsch W ( 2010) XDS. Acta Crystallogr D Biol Crystallogr 66: 125132.
  • 45
    Evans P ( 2006) Scaling and assessment of data quality. Acta Crystallogr D Biol Crystallogr 62: 7282.
  • 46
    McCoy AJ, Grosse-Kunstleve RW, Adams PD, Winn MD, Storoni LC, Read RJ ( 2007) Phaser crystallographic software. J Appl Crystallogr 40: 658674.
  • 47
    Collaborative Computational Project N ( 1994) The CCP4 Suite: programs for protein crytsallography. Acta Crystallogr D Biol Crystallogr D50: 760763.
  • 48
    Bricogne G, Blanc E, Brandl M, Flensburg C, Keller P, Paciorek P, Roversi P, Sharff A, Smart O, Vonrhein C, Womack T ( 2010) BUSTER version 2.9. Cambridge, United Kingdom: Global Phasing Ltd.
  • 49
    Emsley P, Cowtan K ( 2004) Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr 60: 21262132.
  • 50
    Smart OS, Brandl M, Flensburg C, Keller P, Paciorek W, Vonrhein C, Womack TO, Bricogne G ( 2008) Refinement with local structure similarity restraints (LSSR) enables exploitation of information from related structures and facilitates use of NCS. Abstr Annu Meet Am Crystallogr Assoc, Knoxville, TN. abstr. TP139.