Serum insulin-like growth factor binding protein-3/prostate-specific antigen ratio is a useful predictive marker in patients with advanced prostate cancer
Version of Record online: 19 DEC 2002
Copyright © 2003 Wiley-Liss, Inc.
Volume 54, Issue 2, pages 125–132, 1 February 2003
How to Cite
Miyata, Y., Sakai, H., Hayashi, T. and Kanetake, H. (2003), Serum insulin-like growth factor binding protein-3/prostate-specific antigen ratio is a useful predictive marker in patients with advanced prostate cancer. Prostate, 54: 125–132. doi: 10.1002/pros.10175
- Issue online: 20 DEC 2002
- Version of Record online: 19 DEC 2002
- Manuscript Accepted: 5 JUL 2002
- Manuscript Received: 6 MAR 2002
- prostate cancer;
- predictive value
Insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) play an important role in regulation of prostate cancer cell growth. We studied the prognostic significance of serum IGF-1 and IGFBP-3 levels, and IGF-1/prostate-specific antigen (PSA) and IGFBP-3/PSA ratios in patients with prostate cancer.
Serum levels of IGF-1, IGFBP-3, and PSA were determined in 112 patients diagnosed with prostate cancer. Serum samples from 32 patients with histologically confined benign prostatatic hyperplasia (BPH) served as control.
Serum IGF-1 levels were significantly higher in advanced prostate cancer (n = 84) than in BPH patients (P < 0.01). IGFBP-3 levels were significantly lower in patients with advanced prostate cancer than in localized tumor (n = 28) or BPH (P < 0.05, each). Univariate analysis showed that serum PSA, IGF-1/PSA ratio, IGFBP-3/PSA ratio, T, N and M classifications correlated significantly with relapse-free survival of advanced prostate cancer patients treated with hormonal therapy. Multivariate analysis identified IGFBP-3/PSA ratio as the only significant variable for relapse-free survival (odds ratio 5.81, 95% CI 1.57–21.51). IGFBP-3/PSA ratio was also an independent predictor of cause-specific survival (stepwise analysis, odds ratio 4.86, P < 0.01).
Our results suggested that IGFBP-3/PSA ratio might be a useful prognostic marker of advanced prostate cancer. Prostate 54: 125–132, 2003. © 2002 Wiley-Liss, Inc.