This study was performed at Garvan Institute of Medical Research, St. Vincent's Hospital, Darlinghurst, Sydney, NSW, 2010 Australia.
Loss of BMP2, Smad8, and Smad4 expression in prostate cancer progression†
Article first published online: 11 DEC 2003
Copyright © 2004 Wiley-Liss, Inc.
Volume 59, Issue 3, pages 234–242, 15 May 2004
How to Cite
Horvath, L. G., Henshall, S. M., Kench, J. G., Turner, J. J., Golovsky, D., Brenner, P. C., O'Neill, G. F., Kooner, R., Stricker, P. D., Grygiel, J. J. and Sutherland, R. L. (2004), Loss of BMP2, Smad8, and Smad4 expression in prostate cancer progression. Prostate, 59: 234–242. doi: 10.1002/pros.10361
- Issue published online: 19 MAR 2004
- Article first published online: 11 DEC 2003
- Manuscript Accepted: 16 OCT 2003
- Manuscript Received: 19 MAY 2003
- National Health and Medical Research Council of Australia (NHMRC)
- Cancer Council New South Wales
- Freedman Foundation
- RT Hall Trust
- Ronald Geoffrey Arnott Foundation
- Prostate Cancer Foundation of Australia
- David Wilson Trust
- radical prostatectomy;
- prostate cancer
The role of the bone morphogenetic protein (BMP) pathway in prostate cancer (PC) is unclear. This study aimed to characterize aspects of the BMP pathway in PC by assessing BMP2, Smad8, and Smad4 expression in normal, hyperplastic, and malignant prostate tissue, and to correlate findings with progression to PC.
Radical prostatectomy (RP) specimens from 74 patients with clinically localized PC (median follow-up 51 months, range 15–152), 44 benign prostatic hypertrophy (BPH) lesions, and 4 normal prostates (NPs) were assessed for BMP2, Smad8, and Smad4 expression using immunohistochemistry.
Both BMP2 (P < 0.001) and nuclear Smad4 (P < 0.0001) expression were significantly decreased in PC compared to benign prostate tissue. Nuclear Smad8 was present in normal/benign prostate tissue but absent in PC and adjacent hyperplasia. Furthermore, loss of BMP2 (P < 0.001) and decreased nuclear Smad4 (P = 0.05) expression correlated with increasing Gleason score.
These data suggest that decreased BMP2, nuclear smad8 and nuclear Smad4 expression are associated with the progression to PC, and in particular loss of BMP2 and Smad4 are related to progression to a more aggressive phenotype. © 2004 Wiley-Liss, Inc.