The work was performed at New York Medical College (NYMC), Valhalla, NY.
Article first published online: 14 OCT 2004
Copyright © 2004 Wiley-Liss, Inc.
Volume 63, Issue 2, pages 169–186, 1 May 2005
How to Cite
Reyes, I., Reyes, N., Iatropoulos, M., Mittelman, A. and Geliebter, J. (2005), Aging-associated changes in gene expression in the ACI rat prostate: Implications for carcinogenesis. Prostate, 63: 169–186. doi: 10.1002/pros.20164
Ismael Reyes and Niradiz Reyes contributed equally to the study.
Niradiz Reyes is currently Director of Research, Corporacion Universitaria Rafael Nuñez (CURN), Cartagena, Colombia.
- Issue published online: 3 MAR 2005
- Article first published online: 14 OCT 2004
- Manuscript Accepted: 26 JUL 2004
- Manuscript Received: 20 MAY 2004
- NCI. Grant Number: 1R21CA88982
- AICR. Grant Number: 97A072
- oxidative stress;
- prostate cancer
Prostate cancer is the most frequently diagnosed neoplasm and the second leading cause of cancer-related mortality in men. Although the incidence of prostate cancer increases with age, the link between aging and prostate cancer is poorly understood.
Affymetrix oligonucleotide microarrays were used to analyze the mRNA expression levels in the dorsolateral prostates from 6- and 18-month-old ACI rats. Real-time RT-PCR and immunohistochemistry was performed to validate microarray data in a select set of genes.
Microarray analysis revealed changes in gene expression associated with inflammation, oxidative stress, tissue remodeling, and energy metabolism. Most of these changes have been related to increased proliferative status of the prostate, anti-apoptosis, activated stroma, and alteration of the energy metabolism.
Age-associated alterations in the gene expression profile may put the aging prostate in risk for the initiation, promotion, and progression of neoplastic transformation in both our animal model and humans. © 2004 Wiley-Liss, Inc.